Evidence map›Paper›PMID 32370061›Full record

Trial reportNutrients2020

A Pilot Screening of Agro-Food Waste Products as Sources of Nutraceutical Formulations to Improve Simulated Postprandial Glycaemia and Insulinaemia in Healthy Subjects.

Gian Carlo Tenore, Domenico Caruso, Maria D'Avino, Giuseppe Buonomo, Giuseppe Caruso, Roberto Ciampaglia, Elisabetta Schiano, Maria Maisto, Giuseppe Annunziata, Ettore Novellino

Open access · goldAbstract readRandomized Controlled Trial
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Antioxidant and Anti-Diabetic Properties of Olive (Antioxidants (Basel, Switzerland) · 2023
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Valorization of Tomato Waste as a Source of Carotenoids.Molecules (Basel, Switzerland) · 2021
    Review
  14. Review
  15. Valorisation ofFoods (Basel, Switzerland) · 2021
    Article
  16. Nanonutraceuticals: The New Frontier of Supplementary Food.Nanomaterials (Basel, Switzerland) · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gian Carlo TenoreDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-0251-9936
Domenico CarusoDepartment of Internal Medicine, Hospital Cardarelli, Via Antonio Cardarelli, 80131 Naples, Italy.
Maria D'AvinoDepartment of Internal Medicine, Hospital Cardarelli, Via Antonio Cardarelli, 80131 Naples, Italy.
Giuseppe BuonomoCoop. Samnium Medica, Viale C. Colombo 18, 82037 Benevento, Italy.
Giuseppe CarusoDepartment of Emergency, Hospital Cardarelli, Via Antonio Cardarelli, 80131 Naples, Italy.
Roberto CiampagliaDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
Elisabetta SchianoDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
Maria MaistoDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-0340-2254
Giuseppe AnnunziataDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.ORCID 0000-0002-1922-662X
Ettore NovellinoDepartment of Pharmacy, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy.
University of Naples Federico II · ITOspedale Antonio Cardarelli · ITSamnium Medica · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The control of glucose homeostasis is the main goal for both the prevention and management of diabetes and pre-diabetes. Numerous drugs are available, despite their side effects. This is constantly leading people to be inclined to natural alternative treatments. Evidence indicates antioxidant-based nutraceuticals as an optimal tool for the glycaemic control. Currently, a great interest has been focused on the valorisation of agro-food by-products as sources of bioactive compounds including polyphenols. In this sense, we tested the efficacy of novel nutraceutical products based on polyphenolic extract from nectarines (NecP), tomato peels (TP), and olive leaves (EOL) on glycaemic and insulinemic responses. The three formulations contained, respectively, 0.007 mg abscisic acid (ABA)/g, 0.5 mg carotenoids/g, and 150 mg oleuropein/g. Twenty healthy subjects consumed a regular glucose solution (RG) or a treatment beverage (TB) obtained by mixing RG with the individual formulations (TB NecP, TB EOL, and TB TP), separately, and on different days. All three formulations significantly lowered the 30 min glucose plasma peak (

Indexed as

AntioxidantsDietary SupplementsFoodHealthy VolunteersPilot ProjectsRefuse DisposalAdolescentAdultAgedBlood GlucoseDiabetes MellitusDouble-Blind MethodFemaleGlycemic ControlHumansInsulinAntioxidantsBlood GlucoseInsulinPolyphenolsWaste Productsabscisic acidcarotenoidsglucose homeostasisnutraceuticalOGTToleuropein

Identifiers

PMID32370061
PMCPMC7282253
OpenAlexW3022057114

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.