ArticleEuropean journal of applied physiology2020
The effect of caffeine on cognitive performance is influenced by CYP1A2 but not ADORA2A genotype, yet neither genotype affects exercise performance in healthy adults.
Article in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Pooled it
- Does ergogenic effect of caffeine supplementation depend on CYP1A2 genotypes? A systematic review with meta-analysis.Journal of sport and health science · 2024Pooled it
- CYP1A2 genotype and acute ergogenic effects of caffeine intake on exercise performance: a systematic review.European journal of nutrition · 2021Pooled it
- The Effect of CYP1A2 Gene Polymorphisms on Caffeine Pharmacokinetics and Exercise Performance in Male Recreational Athletes.European journal of sport science · 2026Trial
- The effects of mental fatigue and caffeine on basketball performance: insights from a crossover study.Journal of the International Society of Sports Nutrition · 2025Trial
- Caffeine exacerbates exercise-induced gut cell damage and is influenced by ADORA2A genotype but not CYP1A2 genotype: A preliminary study.Physiological reports · 2025Trial
- The dose-dependent effect of caffeine supplementation on performance, reaction time and postural stability in CrossFit - a randomized placebo-controlled crossover trial.Journal of the International Society of Sports Nutrition · 2024Trial
- Influence of the CYP1A2 c.European journal of nutrition · 2024Trial
- Effect ofNutrients · 2024Trial
- The effect of caffeine on exercise performance is not influenced by ADORA2A genotypes, alone or pooled with CYP1A2 genotypes, in adolescent athletes.European journal of nutrition · 2023Trial
- Trial
- Trial
- Caffeine and Sports Performance: The Conflict between Caffeine Intake to Enhance Performance and Avoiding Caffeine to Ensure Sleep Quality.Sports medicine (Auckland, N.Z.) · 2025Review
- Habitual caffeine intake, genetics and cognitive performance.Journal of psychopharmacology (Oxford, England) · 2025Article
- Stable interindividual differences in modafinil's effect on vigilance during sleep deprivation.Frontiers in pharmacology · 2025Article
- Towards Precision Sports Nutrition for Endurance Athletes: A Scoping Review of Application of Omics and Wearables Technologies.Nutrients · 2024Article
- The Effects of Caffeine on Blood Platelets and the Cardiovascular System through Adenosine Receptors.International journal of molecular sciences · 2024Review
- Exploring the relationship between caffeine metabolism-related CYP1A2 rs762551 polymorphism and team sport athlete status and training adaptations.Molecular biology reports · 2024Article
- Combined long-term enriched environment and caffeine supplementation improve memory function in C57Bl6 mice.European archives of psychiatry and clinical neuroscience · 2023Article
- Evaluation of Caffeine Ingested Timing on Endurance Performance based on CYP1A2 rs762551 Profiling in Healthy Sedentary Young Adults.Reports of biochemistry & molecular biology · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the influence of two commonly occurring genetic polymorphisms on exercise, cognitive performance, and caffeine metabolism, after caffeine ingestion.
methodsEighteen adults received caffeine or placebo (3 mg kg
resultsCaffeine enhanced exercise performance (P < 0.001), but effects were not different between participants with ADORA2A 'high' (n = 11) vs. 'low' (n = 7) sensitivity genotype (+ 6.4 ± 5.8 vs. + 8.2 ± 6.8%), or CYP1A2 'fast' (n = 10) vs. 'slow' (n = 8) metabolism genotype (+ 7.2 ± 5.9 vs. + 7.0 ± 6.7%, P > 0.05). Caffeine enhanced PVT performance (P < 0.01). The effect of caffeine was greater for CYP1A2 'fast' vs. 'slow' metabolisers for reaction time during exercise (- 18 ± 9 vs. - 1.0 ± 11 ms); fastest 10% reaction time at rest (- 18 ± 11 vs. - 3 ± 15 ms) and lapses at rest (- 3.8 ± 2.7 vs. + 0.4 ± 0.9) (P < 0.05). There were no PVT differences between ADORA2A genotypes (P > 0.05). Serum caffeine and paraxanthine responses were not different between genotypes (P > 0.05).
conclusionCaffeine enhanced CYP1A2 'fast' metabolisers' cognitive performance more than 'slow' metabolisers. No other between-genotype differences emerged for the effect of caffeine on exercise or cognitive performance, or metabolism.
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