ArticleProceedings of the National Academy of Sciences of the United States of America2020
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
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Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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0cells of the map it votes in
27citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
What it found
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- Double strand breaks drive toxicity in a Huntington's disease mouse model with or without somatic expansion.Nature communications · 2026Article
- Fructose-2,6-bisphosphate restores TDP-43 pathology-driven genome repair deficiency in motor neuron diseases.Communications biology · 2026Article
- The multiple layers of RNA response in double-strand break repair.Experimental & molecular medicine · 2025Review
- Gene editing for Spinocerebellar ataxia type 3 taking advantage of the human ATXN3L paralog as replacement gene.Gene therapy · 2025Article
- Huntingtin preserves mitochondrial genome integrity in neurons, which is impaired in Huntington's disease.bioRxiv : the preprint server for biology · 2025Article
- Deaminase-Driven Reverse Transcription Mutagenesis in Oncogenesis: Critical Analysis of Transcriptional Strand Asymmetries of Single Base Substitution Signatures.International journal of molecular sciences · 2025Review
- Transcription-coupled DNA repair protects genome stability upon oxidative stress-derived DNA strand breaks.FEBS letters · 2025Review
- Ubiquitin system mutations in neurological diseases.Trends in biochemical sciences · 2024Review
- ATXN3: a multifunctional protein involved in the polyglutamine disease spinocerebellar ataxia type 3.Expert reviews in molecular medicine · 2024Review
- Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease.bioRxiv : the preprint server for biology · 2024Article
- Site-specific acetylation of polynucleotide kinase 3'-phosphatase regulates its distinct role in DNA repair pathways.Nucleic acids research · 2024Article
- Regulation of DNA damage response by trimeric G-proteins.iScience · 2023Article
- Assays with Patient-Derived Organoids to Evaluate the Impact of Microbial Infection on Base Excision Repair (BER) Enzymes.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Highly Sensitive Radioactivity-Based DNA 3'-Phosphatase Activity Assay for Polynucleotide Kinase 3'-Phosphatase.Methods in molecular biology (Clifton, N.J.) · 2023Article
- The equilibrium of tumor suppression: DUBs as active regulators of PTEN.Experimental & molecular medicine · 2022Review
- miRNA-Mediated Knockdown of ATXN3 Alleviates Molecular Disease Hallmarks in a Mouse Model for Spinocerebellar Ataxia Type 3.Nucleic acid therapeutics · 2022Article
- Mechanistic and Therapeutic Insights into Ataxic Disorders with Pentanucleotide Expansions.Cells · 2022Review
- DNA Double-Strand Breaks as Pathogenic Lesions in Neurological Disorders.International journal of molecular sciences · 2022Review
- Polymerases and DNA Repair in Neurons: Implications in Neuronal Survival and Neurodegenerative Diseases.Frontiers in cellular neuroscience · 2022Review
Corrections and comments
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Authors and funding
15 authors at 5 institutions in 2 countries.
Anirban ChakrabortyDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Texas Medical Branch, Galveston, TX 77555.
Nisha TapryalDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Texas Medical Branch, Galveston, TX 77555.
Tatiana VenkovaDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Texas Medical Branch, Galveston, TX 77555.ORCID 0000-0002-1586-5600
Joy MitraDepartment of Neurosurgery, Center for Neuroregeneration, The Houston Methodist Research Institute, Houston, TX 77030.ORCID 0000-0002-5985-0582
Velmarini VasquezDepartment of Neurosurgery, Center for Neuroregeneration, The Houston Methodist Research Institute, Houston, TX 77030.
Altaf H SarkerDepartment of Cancer and DNA Damage Responses, Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720.ORCID 0000-0001-6868-8460
Sara Duarte-SilvaSchool of Medicine, Life and Health Sciences Research Institute, University of Minho, 4710-057 Braga, Portugal.
Weihan HuaiDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.
Tetsuo AshizawaDepartment of Neurology, The Houston Methodist Research Institute, Houston, TX 77030.
Gourisankar GhoshDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA 92093.
Patricia MacielSchool of Medicine, Life and Health Sciences Research Institute, University of Minho, 4710-057 Braga, Portugal.ORCID 0000-0002-0920-6350
Partha S SarkarDepartment of Neurology and Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555.
Muralidhar L HegdeDepartment of Neurosurgery, Center for Neuroregeneration, The Houston Methodist Research Institute, Houston, TX 77030.ORCID 0000-0001-7333-8123
Xu ChenDepartment of Neurosciences, University of California San Diego, La Jolla, CA 92093.ORCID 0000-0001-8926-3090
Tapas K HazraDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of Texas Medical Branch, Galveston, TX 77555; tkhazra@utmb.edu.
The University of Texas Medical Branch at Galveston · USHouston Methodist · USUniversity of California San Diego · USUniversity of Minho · PTLawrence Berkeley National Laboratory · US
Funding
Synthetic Organic Chemistry CoreP30ES006676 · NIEHS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ELFERINK, CORNELIS JOHAN · 1995 to 2017
$21.7MMichigan Alzheimer's Disease Core CenterP30AG053760 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LIEBERMAN, ANDREW P · 2016 to 2020
$10.1MPreferential single-strand break repair in the active genes of mammalian cellsR01NS073976 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HAZRA, TAPAS K · 2012 to 2021
$3.3MMechanism of DNA strand-break repair deficiency in Huntington's diseaseR01NS096305 · NINDS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI HAZRA, TAPAS K, SARKAR, PARTHA S · 2016 to 2020
$2.3MEtiological Linkage of DNA Damage/Repair Deficiency in Neurodegenerative DiseasesR01NS088645 · NINDS · METHODIST HOSPITAL RESEARCH INSTITUTE · PI HEGDE, MURALIDHAR L · 2015 to 2019
$1.8MPathogenic Role of DNA-Damage Response Pathway in the Diabetic RetinaR01EY026089 · NEI · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SARKAR, PARTHA S · 2016 to 2019
$1.4MNEI NIH HHS R01 EY026089NIA NIH HHS P30 AG053760NIEHS NIH HHS P30 ES006676NINDS NIH HHS R01 NS073976NINDS NIH HHS R01 NS088645NINDS NIH HHS R01 NS096305
Abstract
Spinocerebellar ataxia type 3 (SCA3) is a dominantly inherited neurodegenerative disease caused by CAG (encoding glutamine) repeat expansion in the Ataxin-3 (
Indexed as
DNA End-Joining RepairAged, 80 and overAnimalsAnimals, Genetically ModifiedAtaxin-3BrainCell LineDisease Models, AnimalDNA Breaks, Double-StrandedDNA Repair EnzymesDrosophilaFemaleGene Knockdown TechniquesHumansInduced Pluripotent Stem CellsMachado-Joseph DiseaseAtaxin-3ATXN3 protein, humanAtxn3 protein, mouseDNA Repair EnzymesPeptidesPhosphotransferases (Alcohol Group Acceptor)PNKP protein, humanPnkp protein, mousepolyglutamineRepressor ProteinsRNA Polymerase IIRNA, Small InterferingATXN3DNA double-strand break repairPNKPRNA-templated TC-NHEJspinocerebellar ataxia type-3
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.