Evidence map›Paper›PMID 31996711›Full record

ArticleScientific reports2020

Insulin-independent stimulation of skeletal muscle glucose uptake by low-dose abscisic acid via AMPK activation.

Mirko Magnone, Laura Emionite, Lucrezia Guida, Tiziana Vigliarolo, Laura Sturla, Sonia Spinelli, Ambra Buschiazzo, Cecilia Marini, Gianmario Sambuceti, Antonio De Flora and 5 more

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 40 citations in OpenAlex.

  1. Insulin Resistance and Inflammation.International journal of molecular sciences · 2026
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  15. Amino acid motifs for the identification of novel protein interactants.Computational and structural biotechnology journal · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 1 country.

Mirko MagnoneDepartment of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1, 16132, Genova, Italy. mirko.magnone@unige.it.
Laura EmioniteAnimal Facility, IRCCS Ospedale Policlinico San Martino, Largo Benzi 10, 16132, Genova, Italy.
Lucrezia GuidaDepartment of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1, 16132, Genova, Italy.
Tiziana VigliaroloDepartment of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1, 16132, Genova, Italy.
Laura SturlaDepartment of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1, 16132, Genova, Italy.
Sonia SpinelliDepartment of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1, 16132, Genova, Italy.
Ambra BuschiazzoNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Largo Benzi 10, 16132, Genova, Italy.
Cecilia MariniNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Largo Benzi 10, 16132, Genova, Italy.
Gianmario SambucetiNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Largo Benzi 10, 16132, Genova, Italy.
Antonio De FloraDepartment of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1, 16132, Genova, Italy.
Anna Maria OrengoNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Largo Benzi 10, 16132, Genova, Italy.
Vanessa CossuNuclear Medicine, IRCCS Ospedale Policlinico San Martino, Largo Benzi 10, 16132, Genova, Italy.
Sara FerrandoDepartment of Earth, Environmental and Life Sciences, University of Genova, Corso Europa 26, Genova, Italy.
Ottavia BarbieriAnimal Facility, IRCCS Ospedale Policlinico San Martino, Largo Benzi 10, 16132, Genova, Italy.
Elena ZocchiDepartment of Experimental Medicine, Section of Biochemistry, University of Genova, Viale Benedetto XV, 1, 16132, Genova, Italy. ezocchi@unige.it.
University of Genoa · ITOspedale Policlinico San Martino · ITInstitute of Molecular Bioimaging and Physiology · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abscisic acid (ABA) is a plant hormone active also in mammals where it regulates, at nanomolar concentrations, blood glucose homeostasis. Here we investigated the mechanism through which low-dose ABA controls glycemia and glucose fate. ABA stimulated uptake of the fluorescent glucose analog 2-NBDG by L6, and of [

Indexed as

4-Chloro-7-nitrobenzofurazanAbscisic AcidAMP-Activated Protein Kinase KinasesAnimalsCell LineDeoxyglucoseDiabetes MellitusDisease Models, AnimalGlucoseInsulinMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMuscle, Skeletal2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose4-Chloro-7-nitrobenzofurazanAbscisic AcidAMP-Activated Protein Kinase KinasesDeoxyglucoseGlucoseInsulinLANCL2 protein, ratMembrane ProteinsProtein KinasesRNA, Small InterferingTRPM2 protein, mouseTRPM Cation Channels

Identifiers

PMID31996711
PMCPMC6989460
OpenAlexW3004388368

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.