SynthesisPLoS neglected tropical diseases2020
Systematic review of the effectiveness of selected drugs for preventive chemotherapy for Taenia solium taeniasis.
Synthesis in PLoS neglected tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 37 citations in OpenAlex.
- Repurposing statins for the treatment of larval cestodiases:Parasitology · 2025Article
- Prevention and improved management of serious neurological adverse events during praziquantel-based mass drug administration in a Taenia solium endemic area: Experiences from Madagascar.PLoS neglected tropical diseases · 2025Article
- A novel sustained-release agent based on disulfide-induced recombinant collagen hydrogels for the prevention and treatment ofMicrobiology spectrum · 2025Article
- Acute appendicitis caused byIDCases · 2025Article
- Effect of Community Health Education Intervention on Prevalence and Pig Farmers' Knowledge, Attitudes, and Practices Related to Porcine Cysticercosis in Selected Areas of Tanzania.Veterinary medicine international · 2025Article
- Intestinal parasitic infection with special reference to taeniid tapeworms in school children of Malakand region, Pakistan.Helminthologia · 2024Article
- Repurposing of a library for high-content screening of inhibitors against Echinococcus granulosus.Parasites & vectors · 2024Article
- Spatial transferability of an agent-based model to simulate Taenia solium control interventions.Parasites & vectors · 2023Article
- Challenges and Prospective of Enhancing Hydatid Cyst Chemotherapy by Nanotechnology and the Future of Nanobiosensors for Diagnosis.Tropical medicine and infectious disease · 2023Review
- Evaluation of Kato-Katz and multiplex quantitative polymerase chain reaction performance for clinical helminth infections in Thailand using a latent class analysis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Preformulation and Long-Term Stability Studies of an Optimized Palatable Praziquantel Ethanol-Free Solution for Pediatric Delivery.Pharmaceutics · 2023Article
- Assessment on the efficacy of methods 2 to 5 and method 7 set out in Commission Regulation (EU) No 142/2011 to inactivate relevant pathogens when producing processed animal protein of porcine origin intended to feed poultry and aquaculture animals.EFSA journal. European Food Safety Authority · 2023Article
- Eliminating morbidity caused by neglected tropical diseases by 2030.Revista panamericana de salud publica = Pan American journal of public health · 2023Article
- Diagnosis of Taenia solium infections based on "mail order" RNA-sequencing of single tapeworm egg isolates from stool samples.PLoS neglected tropical diseases · 2021Article
- Foodborne Parasitic Diseases in the Neotropics - A Review.Helminthologia · 2021Article
- Impact of a 3-year mass drug administration pilot project for taeniasis control in Madagascar.PLoS neglected tropical diseases · 2020Article
- The viewpoint by White and colleagues critiquing the evaluation of the safety and efficacy of mass chemotherapy for Taenia solium taeniasis is unsubstantiated.PLoS neglected tropical diseases · 2020Article
- Drug repurposing applied: Activity of the anti-malarial mefloquine against Echinococcus multilocularis.International journal for parasitology. Drugs and drug resistance · 2020Article
- The data are inadequate to assess safety and efficacy of mass chemotherapy for Taenia solium taeniasis.PLoS neglected tropical diseases · 2020Article
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Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
Abstract
backgroundPreventive chemotherapy is a useful tool for the control of Taenia solium taeniasis and cysticercosis. The aim of this systematic review is to assess the scientific evidence concerning the effectiveness and safety of different drugs in preventive chemotherapy for T. solium taeniasis in endemic populations.
methodsA systematic review was conducted of controlled and uncontrolled studies, assessing the efficacy and adverse effects (among other outcomes) of albendazole, niclosamide and/or praziquantel for preventive chemotherapy of T. solium taeniasis. A comprehensive search was conducted for published and unpublished studies. Two reviewers screened articles, completed the data extraction and assessment of risk of bias. A meta-analysis of cure rate and relative reduction in prevalence was performed. The protocol for this review was registered on the International prospective register of systematic reviews (PROSPERO), number CRD42018112533.
resultsWe identified 3555 records, of which we included 20 primary studies reported across 33 articles. Meta-analyses of drug and dose showed that a single dose of praziquantel 10mg/kg, albendazole 400mg per day for three consecutive days, or niclosamide 2g, resulted in better cure rates for T. solium taeniasis (99.5%, 96.4% and 84.3%, respectively) than praziquantel 5mg/kg or single dose albendazole 400mg (89.0% and 52.0%, respectively). These findings have a low certainty of evidence due to high risk of bias in individual studies and heterogeneity in combined estimates. In relation to side-effects, most studies reported either no or only mild and transient side-effects within the first three days following drug administration for all drugs and doses.
conclusionEvidence indicated that praziquantel 10mg/kg, niclosamide 2g, and triple dose albendazole 400mg were effective as taenicides and could be considered for use in mass drug administration programs for the control of T. solium taeniasis. Evidence was not found that any of these drugs caused severe side effects at the indicated doses, although the extent of the available evidence was limited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.