Evidence map›Paper›PMID 31939312›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2020

Deciphering the enzymatic target of a new family of antischistosomal agents bearing a quinazoline scaffold using complementary computational tools.

Victor Sebastian-Perez, Alfonso García-Rubia, Sayed H Seif El-Din, Abdel-Nasser A Sabra, Naglaa M El-Lakkany, Samia William, Tom L Blundell, Louis Maes, Ana Martinez, Nuria E Campillo and 2 more

Abstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Victor Sebastian-PerezCentro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-8248-4496
Alfonso García-RubiaCentro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.
Sayed H Seif El-DinPharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Abdel-Nasser A SabraPharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Naglaa M El-LakkanyPharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Samia WilliamParasitology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Tom L BlundellDepartment of Biochemistry, University of Cambridge, Cambridge, UK.
Louis MaesLaboratory for Microbiology, Parasitology and Hygiene (LMPH), University of Antwerp, Antwerp, Belgium.
Ana MartinezCentro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-2707-8110
Nuria E CampilloCentro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-9948-2665
Sanaa S BotrosPharmacology Department, Theodor Bilharz Research Institute, Giza, Egypt.
Carmen GilCentro de Investigaciones Biológicas (CIB-CSIC), Madrid, Spain.ORCID http://orcid.org/0000-0002-3882-6081

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A previous phenotypic screening campaign led to the identification of a quinazoline derivative with promising

Indexed as

Aldehyde ReductaseAnimalsAnthelminticsDose-Response Relationship, DrugEnzyme InhibitorsMaleMiceModels, MolecularMolecular StructureQuinazolinesSchistosoma mansoniStructure-Activity RelationshipAldehyde ReductaseAnthelminticsEnzyme InhibitorsQuinazolinesDrug discoveryquinazolineSchistosoma mansonitarget deconvolution

Identifiers

PMID31939312
PMCPMC7717570

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.