ArticlePloS one2019
Enzymatic production of bioactive peptides from scotta, an exhausted by-product of ricotta cheese processing.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 46 citations in OpenAlex.
- Geographic provenance and environmental growing conditions as factors influencing phytochemical composition of Arabica green coffee beans.Plant biology (Stuttgart, Germany) · 2026Article
- Substrate Optimization for PHB Production from Ricotta Cheese Exhausted Whey UsingMicroorganisms · 2025Article
- Incorporation of Protein Hydrolysate into Rapeseed Meal-Based Materials to Improve Flexibility.Polymers · 2025Article
- Bioactivity assessment of peptides derived from salted jellyfish (Rhopilema hispidum) byproducts.PloS one · 2025Article
- Sheep's Second Cheese Whey Edible Coatings with Oregano and Clary Sage Essential Oils Used as Sustainable Packaging Material in Cheese.Foods (Basel, Switzerland) · 2024Article
- Upstream and Downstream Bioprocessing in Enzyme Technology.Pharmaceutics · 2023Review
- Peptide OA-VI12 restrains melanogenesis in B16 cells and C57B/6 mouse ear skin via the miR-122-5p/Mitf/Tyr axis.Amino acids · 2023Article
- Propionibacteria as promising tools for the production of pro-bioactive scotta: a proof-of-concept study.Frontiers in microbiology · 2023Article
- Next-generation nutraceuticals: bioactive peptides from plant proteases.Biotechnologia · 2022Review
- Looking for peptides from rice starch processing by-product: Bioreactor production, anti-tyrosinase and anti-inflammatory activity, andFrontiers in plant science · 2022Article
- Exploring the DPP-IV Inhibitory, Antioxidant and Antibacterial Potential of Ovine "Scotta" Hydrolysates.Foods (Basel, Switzerland) · 2021Article
- Antihypertensive Peptides from Ultrafiltration and Fermentation of the Ricotta Cheese Exhausted Whey: Design and Characterization of a Functional Ricotta Cheese.Foods (Basel, Switzerland) · 2021Article
- Valorization of Dairy Wastes: Integrative Approaches for Value Added Products.Indian journal of microbiology · 2021Review
- Dairy By-Products: A Review on the Valorization of Whey and Second Cheese Whey.Foods (Basel, Switzerland) · 2021Review
- Enzymatic Digestion of Calf Fleshing Meat By-Products: Antioxidant and Anti-Tyrosinase Activity of Protein Hydrolysates, and Identification of Fatty Acids.Foods (Basel, Switzerland) · 2021Article
- Advances on Food-Derived Peptidic Antioxidants-A Review.Antioxidants (Basel, Switzerland) · 2020Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present work reports the enzymatic valorisation of the protein fraction of scotta, a dairy by-product representing the exhausted liquid residue of ricotta production. Scotta was subjected to ultra-filtration with membrane cut-offs from 500 to 4 kDa and the obtained protein-enriched fractions were used for the optimization of enzyme-based digestions aimed at producing potentially bioactive peptides. Nine different commercial proteases were tested and the best digestion conditions were selected based on protein yield, fraction bioactivity and foreseen scale up processing costs. Scale up of the 3% Pancreatin or 5% Papain processes was performed up to 2 L (37°C or 60°C respectively, 1 h incubation), and the digestion efficiency increased with the reaction volume as well as antioxidant activity (up to 60 gBSA eq/L and to 1.7 gAA eq/L). Retentate 1 digested fractions also showed, for the first time in dairy-based peptides, anti-tyrosinase activity, up to 0.14 gKA eq/L. Digested proteins were sub-fractionated by means of physical membrane separations and 30-10 kDa fraction from Papain treatment showed the highest antioxidant and anti-tyrosinase activities. The peptide sequence of the most bioactive fractions was achieved.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.