ArticleScientific reports2019
Induced Osteogenesis in Plants Decellularized Scaffolds.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 121 citations in OpenAlex.
- Growing Relevance of Decellularized Plant Material as Functional Scaffolds in Tissue Engineering and Cultured Meat: A Scoping Review on Recent Advances, Challenges, and Future Directions.Annals of biomedical engineering · 2026Review
- Development of a Scaffold from the Cob ofJournal of functional biomaterials · 2026Article
- Implantation of Bioreactor-Conditioned Plant-Based Vascular Grafts.Journal of functional biomaterials · 2026Article
- A multifunctional conductive physiomimetic scaffold: synergy of rGO coating and cannabis-derived nanotopography for infection-resistant bone repair.Frontiers in bioengineering and biotechnology · 2026Article
- Engineering vascular grafts from decellularized plants: Advances and challenges.Histology and histopathology · 2025Review
- Poly-L-Ornithine coated plant scaffolds support motor recovery in rats after traumatic spinal cord injury.Scientific reports · 2025Article
- Trends in non-animal scaffolds for cultured meat structuration.NPJ science of food · 2025Review
- Plant-Based Scaffolds for Tissue Engineering: A Review.Polymers · 2025Review
- Decellularized apple hypanthium as a plant-based biomaterial for cartilage regeneration in vitro: a comparative study of progenitor cell types and environmental conditions.Journal of biological engineering · 2025Article
- The Effect of Nerve Growth Factor on Cartilage Fibrosis and Hypertrophy duringInternational journal of stem cells · 2025Article
- Decellularized Persian walnut leaf (Frontiers in bioengineering and biotechnology · 2025Article
- Decellularized Green and Brown Macroalgae as Cellulose Matrices for Tissue Engineering.Journal of functional biomaterials · 2024Article
- Decellularized Macroalgae as Complex Hydrophilic Structures for Skin Tissue Engineering and Drug Delivery.Gels (Basel, Switzerland) · 2024Article
- Plant-Based Decellularization: A Novel Approach for Perfusion-Compatible Tissue Engineering Structures.Journal of microbiology and biotechnology · 2024Review
- Protective effect of3 Biotech · 2024Article
- Unconventional strategies for liver tissue engineering: plant, paper, silk and nanomaterial-based scaffolds.Regenerative medicine · 2024Review
- Plant Decellularization by Chemical and Physical Methods for Regenerative Medicine: A Review Article.Journal of medical signals and sensors · 2024Review
- Cellulose as a sustainable scaffold material in cultivated meat production.Current research in food science · 2024Article
- Article
- Plant Cellulose as a Substrate for 3D Neural Stem Cell Culture.Bioengineering (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A three-dimensional (3D) culture system that closely replicates the in vivo microenvironment of calcifying osteoid is essential for in vitro cultivation of bone-like material. In this regard, the 3D cellulose constructs of plants may well serve as scaffolds to promote growth and differentiation of osteoblasts in culture. Our aim in this study was to generate bone-like tissue by seeding pluripotent stem cells (hiPSCs), stimulated to differentiate as osteoblasts in culture, onto the decellularised scaffolds of various plants. We then assessed expression levels of pertinent cellular markers and degrees of calcium-specific staining to gauge technical success. Apple scaffolding bearing regular pores of 300 μm seemed to provide the best construct. The bone-like tissue thus generated was implantable in a rat calvarial defect model where if helped form calcified tissue. Depending on the regularity and sizing of scaffold pores, this approach readily facilitates production of mineralized bone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.