SynthesisMolecules (Basel, Switzerland)2019
Dihydrochalcones: Methods of Acquisition and Pharmacological Properties-A First Systematic Review.
Synthesis in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed.
- Influence of Methoxy Substitution Pattern on Cascade Biotransformation of 4'-Hydroxychalcones by Entomopathogenic Fungi.International journal of molecular sciences · 2026Article
- Ultrasound extraction and bioactive flavonoid profiling of Alsophila spinulosa leaves across maturity stages.Ultrasonics sonochemistry · 2026Article
- Assessment of Cellular Apoptosis Induced by Hydroxychalcones in MCC13 Merkel Cells.International journal of molecular sciences · 2026Article
- Design, Synthesis, and Evaluation of New Polyhydroxylated Bis-Chalcones as Potential COX-2 Selective Inhibitors.ChemMedChem · 2026Article
- Recent Advances in the Synthesis and Biological Applications of Prenylated Chalcones.International journal of molecular sciences · 2025Review
- Effect of Sunlight-Induced Isomerisation on the Biotransformation of 4'-Hydroxychalcones byInternational journal of molecular sciences · 2025Article
- The potential of red-fleshed apples for cider production.Comprehensive reviews in food science and food safety · 2025Review
- Therapeutic Perspectives of Aminoflavonoids-A Review.International journal of molecular sciences · 2025Review
- Synergistic Proliferation Effects of Xanthohumol and Niflumic Acid on Merkel and Glioblastoma Cancer Cells: Role of Cell Membrane Interactions.International journal of molecular sciences · 2024Article
- Efficient Production of 4'-Hydroxydihydrochalcones Using Non-Conventional Yeast Strains.International journal of molecular sciences · 2024Article
- Apple Pomace as a Potential Source of Oxidative Stress-Protecting Dihydrochalcones.Antioxidants (Basel, Switzerland) · 2024Article
- Autophagy-induced cell death by aqueous and polyphenol-enriched extracts of honeybush (Food science & nutrition · 2024Article
- Bioreduction of 4'-Hydroxychalcone in Deep Eutectic Solvents: Optimization and Efficacy with Various Yeast Strains.International journal of molecular sciences · 2024Article
- Antibacterial and antioxidant phlorizin-loaded nanofiber film effectively promotes the healing of burn wounds.Frontiers in bioengineering and biotechnology · 2024Article
- Flavonoid as possible therapeutic targets against COVID-19: a scoping review of in silico studies.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2023Article
- Bioactive Compounds from Fruits as Preservatives.Foods (Basel, Switzerland) · 2023Review
- Regiospecific Hydrogenation of Bromochalcone by Unconventional Yeast Strains.Molecules (Basel, Switzerland) · 2022Article
- Synthesis of Asebogenin and Balsacone A Precursor by a Novel Synthetic Strategy: Recent Opportunities for and Challenges of Total Synthesis of Balsacone A.Molecules (Basel, Switzerland) · 2022Article
- Hemisynthesis and Biological Evaluation of Cinnamylated, Benzylated, and Prenylated Dihydrochalcones from a Common Bio-Sourced Precursor.Antibiotics (Basel, Switzerland) · 2021Article
- From Preclinical Stroke Models to Humans: Polyphenols in the Prevention and Treatment of Stroke.Nutrients · 2020Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dihydrochalcones are a class of secondary metabolites, for which demand in biological and pharmacological applications is still growing. They posses several healthendorsing properties and, therefore, are promising candidates for further research and development. However, low content of dihydrochalcones in plants along with their low solubility and bioavailability restrict the development of these compounds as clinical therapeutics. Therefore, chemomicrobial and enzymatic modifications are required to expand their application. This review aims at analyzing and summarizing the methods of obtaining dihydrochalcones and of presenting their pharmacological actions that have been described in the literature to support potential future development of this group of compounds as novel therapeutic drugs. We have also performed an evaluation of the available literature on beneficial effects of dihydrochalcones with potent antioxidant activity and multifactorial pharmacological effects, including antidiabetic, antitumor, lipometabolism regulating, antioxidant, antiinflammatory, antibacterial, antiviral, and immunomodulatory ones. In addition, we provide useful information on their properties, sources, and usefulness in medicinal chemistry.
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