ArticleInflammopharmacology2020
An ethyl-acetate fraction of Holothuria scabra modulates inflammation in vitro through inhibiting the production of nitric oxide and pro-inflammatory cytokines via NF-κB and JNK pathways.
Article in Inflammopharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 25 citations in OpenAlex.
- Unveiling the Hidden Biotechnological Potential of the Vermetid Gastropod Vermetus triquetrus: Insights into an Unexplored Marine Resource.Marine biotechnology (New York, N.Y.) · 2026Article
- Modulation of inflammatory and oxidative stress pathways by polyphenol-rich Pleurospermum candollei extract in carrageenan-induced paw edema in rats.Inflammopharmacology · 2025Article
- Antioxidative and Regenerative Potential of Sea Cucumber: Focus on Bioactive Compounds and Exosome-Based Strategies for Combating Skin Oxidative Stress.Clinical, cosmetic and investigational dermatology · 2025Review
- Investigating the potential effect of Holothuria scabra extract on osteogenic differentiation in preosteoblast MC3T3-E1 cells.Scientific reports · 2024Article
- How Biological Activity in Sea Cucumbers Changes as a Function of Species and Tissue.Foods (Basel, Switzerland) · 2023Article
- Article
- Antioxidant and Anti-inflammatory Activity of Sea Cucumber (Bioinformatics and biology insights · 2023Article
- 2-Butoxytetrahydrofuran and Palmitic Acid fromPharmaceuticals (Basel, Switzerland) · 2022Article
- Anti-Inflammatory Effects of Compounds from Echinoderms.Marine drugs · 2022Review
- Antioxidant Potential of Sea Cucumbers and Their Beneficial Effects on Human Health.Marine drugs · 2022Review
- Thiamine Demonstrates Bio-Preservative and Anti-Microbial Effects in Minced Beef Meat Storage and Lipopolysaccharide (LPS)-Stimulated RAW 264.7 Macrophages.Animals : an open access journal from MDPI · 2022Article
- Phenolic Compounds and Antioxidant Capacity of Sea Cucumber (Antioxidants (Basel, Switzerland) · 2022Article
- In vitro and in vivo anti-inflammatory activity of Tetrastigma sulcatum leaf extract, pure compound and its derivatives.Inflammopharmacology · 2022Article
- Methanolic Extract from Sea Cucumber,Journal of microbiology and biotechnology · 2021Article
- Anti-Inflammatory Activity of Sanjie Zhentong Capsule Assessed By Network Pharmacology Analysis of Adenomyosis Treatment.Drug design, development and therapy · 2020Article
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sea cucumber, Holothuria scabra, is an echinoderm marine animal that has long been used as a traditional therapeutic in various diseases due to its chemical composition and protein enrichment. Many researchers have extensively studied the efficacy of sea cucumber extracts for many health benefits in recent years. Inflammation is a complex process involved in pro-/anti-inflammatory cytokine products. However, the role of the H. scabra extracts in anti-inflammation and its molecular regulations has not been apparently elucidated yet. In this study, we investigated the anti-inflammatory effect of H. scabra extracts by using lipopolysaccharide (LPS) from E. coli to induce an inflammatory response in RAW264.7 macrophage. It was found that ethyl acetate fraction of H. scabra extracts (EAHS) inhibited pro-inflammatory cytokines synthesis at both the transcriptional and translational levels, notably nitric oxide (NO), inducible nitric oxide synthase (iNOS), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and prostaglandin E
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