Evidence map›Paper›PMID 31623400›Full record

Trial reportNutrients2019

Effects of L-Theanine Administration on Stress-Related Symptoms and Cognitive Functions in Healthy Adults: A Randomized Controlled Trial.

Shinsuke Hidese, Shintaro Ogawa, Miho Ota, Ikki Ishida, Zenta Yasukawa, Makoto Ozeki, Hiroshi Kunugi

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 75 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
75citing papers in PubMed, 7 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05450952 naterminatednot on this mapstarted 2022, after this paper: background citation

A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Theanine Formulation on Stress, Burnout, Mood, and Sleep in Individuals Who Report Occasional Moderate or High Levels of Stress

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2022 to 2022Enrolled14ConditionsStressArmsTheanine Formulation, Placebo
NCT05854017 nacompletednot on this mapstarted 2023, after this paper: background citation

A Double-blind, Randomized, Placebo-controlled Study to Evaluate the Effects of a Theanine for Stress Relief Formulation on Stress, Burnout Component, Mood, and Sleep in Individuals Who Report Occasional Moderate or High Levels of Stress

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2023 to 2025Enrolled104ConditionsStressArmsTheanine for stress relief formulation, Placebo
3 · Its place in the literature

Who cites it

75 citing papers in PubMed, 7 syntheses or guidelines pooled it, 141 citations in OpenAlex.

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15 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shinsuke HideseDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan. shidese@ncnp.go.jp.ORCID 0000-0001-7541-2075
Shintaro OgawaDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan. sogawa@ncnp.go.jp.
Miho OtaDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan. ota@ncnp.go.jp.
Ikki IshidaDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan. iishida@ncnp.go.jp.
Zenta YasukawaDepartment of Research and Development, Nutrition Division, Taiyo Kagaku Co. Ltd, 1-3, Takara-machi, Yokkaichi, Mie 510-0844, Japan. zyasukawa@taiyokagaku.co.jp.
Makoto OzekiDepartment of Research and Development, Nutrition Division, Taiyo Kagaku Co. Ltd, 1-3, Takara-machi, Yokkaichi, Mie 510-0844, Japan. mozeki@taiyokagaku.co.jp.
Hiroshi KunugiDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo 187-8502, Japan. hkunugi@ncnp.go.jp.ORCID 0000-0002-7209-3790
National Center of Neurology and Psychiatry · JPTaiyo Yuden (Japan) · JP

Funding

Funding received from Taiyo Kagaku Co., Ltd., Mie, Japan. None
6 · The paper itself

Abstract

This randomized, placebo-controlled, crossover, and double-blind trial aimed to examine the possible effects of four weeks L-theanine administration on stress-related symptoms and cognitive functions in healthy adults. Participants were 30 individuals (nine men and 21 women; age: 48.3 ± 11.9 years) who had no major psychiatric illness. L-theanine (200 mg/day) or placebo tablets were randomly and blindly assigned for four-week administration. For stress-related symptoms, Self-rating Depression Scale, State-Trait Anxiety Inventory-trait, and Pittsburgh Sleep Quality Index (PSQI) scores decreased after L-theanine administration (

Indexed as

AdultAnxietyBody Mass IndexCognitionCross-Over StudiesDepressionDouble-Blind MethodFemaleGlutamatesHumansMaleMiddle AgedPlacebosSleep Wake DisordersStress, PsychologicalGlutamatesPlacebostheaninecognitionemotionL-theaninesleepstress

Identifiers

PMID31623400
PMCPMC6836118
OpenAlexW2977908783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.