Observational studyMetabolomics : Official journal of the Metabolomic Society2019
Relationship between the lipid composition of maternal plasma and infant plasma through breast milk.
Observational study in Metabolomics : Official journal of the Metabolomic Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Comparative Analysis of Omega-3, Omega-6, and Endocannabinoid Content of Human, Cattle, Goat, and Formula Milk.Foods (Basel, Switzerland) · 2025Article
- Metabolomics Approach to Identify Biomarkers of Acute and Subacute Mastitis in Milk Samples: A Pilot Case-Control Study.Metabolites · 2024Article
- Key questions and gaps in understanding adipose tissue macrophages and early-life metabolic programming.American journal of physiology. Endocrinology and metabolism · 2024Review
- Comparative lipidome study of maternal plasma, milk, and lamb plasma in sheep.Scientific reports · 2024Article
- Respiratory Virus-Specific Nasopharyngeal Lipidome Signatures and Severity in Infants With Bronchiolitis: A Prospective Multicenter Study.The Journal of infectious diseases · 2023Article
- Maternal and Child Health, Non-Communicable Diseases and Metabolites.Metabolites · 2023Review
- Defining the lipid profiles of human milk, infant formula, and animal milk: implications for infant feeding.Frontiers in nutrition · 2023Article
- Comparison of Workflows for Milk Lipid Analysis: Phospholipids.Foods (Basel, Switzerland) · 2022Article
- Metabolic impact of adipose tissue macrophages in the early postnatal life.Journal of leukocyte biology · 2022Review
- The Role of Human Milk Lipids and Lipid Metabolites in Protecting the Infant against Non-Communicable Disease.International journal of molecular sciences · 2022Review
- Metabolomics in early life and the association with body composition at age 2 years.Pediatric obesity · 2022Article
- Metabolomics Signatures and Subsequent Maternal Health among Mothers with a Congenital Heart Defect-Affected Pregnancy.Metabolites · 2022Article
- Influence of gestational diabetes mellitus on lipid signatures in breast milk and association with fetal physical development.Frontiers in nutrition · 2022Article
- Co-Evolution of Breast Milk Lipid Signaling and Thermogenic Adipose Tissue.Biomolecules · 2021Review
- A high-throughput platform for detailed lipidomic analysis of a range of mouse and human tissues.Analytical and bioanalytical chemistry · 2020Article
- Altered triglyceride and phospholipid metabolism predates the diagnosis of gestational diabetes in obese pregnancy.Molecular omics · 2019Article
- Fermentation of Milk into Yoghurt and Cheese Leads to Contrasting Lipid and Glyceride Profiles.Nutrients · 2019Article
- The Lipid and Glyceride Profiles of Infant Formula Differ by Manufacturer, Region and Date Sold.Nutrients · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
introductionThis study was motivated by the report that infant development correlates with particular lipids in infant plasma.
objectiveThe hypothesis was that the abundance of these candidate biomarkers is influenced by the dietary intake of the infant.
methodsA cohort of 30 exclusively-breastfeeding mother-infant pairs from a small region of West Africa was used for this observational study. Plasma and milk from the mother and plasma from her infant were collected within 24 h, 3 months post partum. The lipid, sterol and glyceride composition was surveyed using direct infusion MS in positive and negative ion modes. Analysis employed a combination of univariate and multivariate tests.
resultsThe lipid profiles of mother and infant plasma samples are similar but distinguishable, and both are distinct from milk. Phosphatidylcholines (PC), cholesteryl esters (CEs) and cholesterol were more abundant in mothers with respect to their infants, e.g. PC(34:1) was 5.66% in mothers but 3.61% in infants (p = 3.60 × 10
conclusionThis study found evidence that the abundance of individual lipid isoforms associated with infant development are associated with the abundance of individual molecular species in the mother's circulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.