Evidence map›Paper›PMID 31273641›Full record

ArticlePlant foods for human nutrition (Dordrecht, Netherlands)2019

Analysis of Wild Raspberries (Rubus idaeus L.): Optimization of the Ultrasonic-Assisted Extraction of Phenolics and a New Insight in Phenolics Bioaccessibility.

Nevena R Mihailović, Vladimir B Mihailović, Andrija R Ćirić, Nikola Z Srećković, Mirjana R Cvijović, Ljubinka G Joksović

Abstract read
PubMed Publisher
In one paragraph

Article in Plant foods for human nutrition (Dordrecht, Netherlands), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Bioactivity and Chemical Profile ofFoods (Basel, Switzerland) · 2022
    Article
  9. Article
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Nevena R MihailovićFaculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, Kragujevac, 34000, Serbia.
Vladimir B MihailovićFaculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, Kragujevac, 34000, Serbia.
Andrija R ĆirićFaculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, Kragujevac, 34000, Serbia.
Nikola Z SrećkovićFaculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, Kragujevac, 34000, Serbia.
Mirjana R CvijovićFaculty of Medicine, Institute for Microbiology and Immunology, University of Belgrade, Dr Subotića 1, Belgrade, 11000, Serbia.
Ljubinka G JoksovićFaculty of Science, Department of Chemistry, University of Kragujevac, R. Domanovića 12, Kragujevac, 34000, Serbia. ljubinka@kg.ac.rs.ORCID http://orcid.org/0000-0001-8781-6915
University of Kragujevac · RSUniversity of Belgrade · RS

Funding

Ministarstvo Prosvete, Nauke i Tehnološkog Razvoja Grants no. OI 172016, III 43004 and OI 175039
6 · The paper itself

Abstract

A simple and efficient ultrasonic-assisted extraction (UAE) technique was developed in order to find optimal conditions for the extraction of total phenolic compounds, flavonoids and anthocyanins in wild raspberry (Rubus idaeus L.) fruits. Several extraction variables, including methanol composition (v/v, %), solid-solvent ratio (g/mL), time (min) and extraction temperature (°C) were optimized using response surface methodology (RSM). Under optimal conditions for extraction, the total phenolics were found in the concentration of 383 mg GAE/100 g of fresh fruit weight, while HPLC-PDA analysis of the optimized extract showed the presence of cyanidin-3-glucoside, cyanidin-3-sophoroside, catechin, gallic and ellagic acid. The experimental values of DPPH and ABTS radical scavenging activities were 29.0 and 39.5 μmol Trolox/g of fresh fruit weight, respectively. In vitro simulated gastrointestinal digestion showed great raspberry phenolics stability. Our study assessed the bioaccessible phenolics in wild raspberry fruits and showed optimal conditions for the effective extraction of bioactive compounds for their analysis.

Indexed as

AnthocyaninsChromatography, High Pressure LiquidFlavonoidsFruitPhenolsPhytochemicalsPlant ExtractsRubusSonicationAnthocyaninsFlavonoidsPhenolsPhytochemicalsPlant ExtractsAntioxidant activityCyanidin-3-glucosideExtractionHPLC-PDAIn vitro digestionRubus idaeus L.

Identifiers

PMID31273641
OpenAlexW2954235642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.