Evidence map›Paper›PMID 31244050›Full record

ArticleACS chemical neuroscience2019

Oleocanthal-Rich Extra-Virgin Olive Oil Restores the Blood-Brain Barrier Function through NLRP3 Inflammasome Inhibition Simultaneously with Autophagy Induction in TgSwDI Mice.

Sweilem B Al Rihani, Lucy I Darakjian, Amal Kaddoumi

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS chemical neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.

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  4. Effects of High-Phenolic Extra Virgin Olive Oil on Sensory Processing in Children With Autism Spectrum Disorder: A Pilot Study.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Sweilem B Al RihaniDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Pharmacy Research Building , Auburn University , Auburn , Alabama 36849 , United States.
Lucy I DarakjianDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Pharmacy Research Building , Auburn University , Auburn , Alabama 36849 , United States.
Amal KaddoumiDepartment of Drug Discovery and Development, Harrison School of Pharmacy, Pharmacy Research Building , Auburn University , Auburn , Alabama 36849 , United States.ORCID 0000-0001-9792-7766
Auburn University · US

Funding

Targeting cerebrovascular endothelial cells as a therapeutic approach for amyloid pathogenesisR15NS091934 · NINDS · UNIVERSITY OF LOUISIANA AT MONROE · PI KHALIL KADDOUMI, AMAL F · 2015 to 2015
$420k
NINDS NIH HHS R15 NS091934
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by multiple hallmarks including extracellular amyloid (Aβ) plaques, neurofibrillary tangles, dysfunctional blood-brain barrier (BBB), neuroinflammation, and impaired autophagy. Thus, novel strategies that target multiple disease pathways would be essential to prevent, halt, or treat the disease. A growing body of evidence including our studies supports a protective effect of oleocanthal (OC) and extra-virgin olive oil (EVOO) at early AD stages before the onset of pathology. In addition, we reported previously that OC and EVOO exhibited such effect by restoring the BBB function; however, the mechanism(s) by which OC and EVOO exert such an effect and whether this effect extends to a later stage of AD remain unknown. In this work, we sought first to test the effect of OC-rich EVOO consumption at an advanced stage of the disease in TgSwDI mice, an AD mouse model, starting at the age of 6 months for 3 months treatment, and then to elucidate the mechanism(s) by which OC-rich EVOO exerts the observed beneficial effect. Overall findings demonstrated that OC-rich EVOO restored the BBB function and reduced AD-associated pathology by reducing neuroinflammation through inhibition of NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome and inducing autophagy through activation of AMP-activated protein kinase (AMPK)/Unc-51-like autophagy activating kinase 1 (ULK1) pathway. Thus, diet supplementation with OC-rich EVOO could provide beneficial effect to slow or halt the progression of AD.

Indexed as

Administration, OralAldehydesAlzheimer DiseaseAnimalsAutophagyBlood-Brain BarrierBrainCyclopentane MonoterpenesDisease Models, AnimalInflammasomesMiceMice, TransgenicNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinOlive OilPhenolsAldehydesCyclopentane MonoterpenesInflammasomesNeuroprotective AgentsNLR Family, Pyrin Domain-Containing 3 ProteinoleocanthalOlive OilPhenolsAlzheimer’s diseaseautophagyblood−brain barrierextra-virgin olive oilNLRP3 inflammasomeoleocanthal

Identifiers

PMID31244050
PMCPMC6703911
OpenAlexW2951951653

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.