Evidence map›Paper›PMID 31241898›Full record

ArticleACS chemical biology2019

Folding Then Binding vs Folding Through Binding in Macrocyclic Peptide Inhibitors of Human Pancreatic α-Amylase.

Leander Goldbach, Bram J A Vermeulen, Sami Caner, Minglong Liu, Christina Tysoe, Lieke van Gijzel, Ryoji Yoshisada, Mikael Trellet, Hugo van Ingen, Gary D Brayer and 2 more

Open access · hybridAbstract read
In one paragraph

Article in ACS chemical biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Mechanistic study of quercetin onFood chemistry: X · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Enhancing glycan stabilityChemical science · 2020
    Article
  9. Article
  10. Cyclic peptides can engage a single binding pocket through highly divergent modes.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Leander Goldbach
Bram J A VermeulenORCID 0000-0002-9798-6245
Sami Caner
Minglong LiuDepartment of Chemical Biology and Drug Discovery , Utrecht Institute of Pharmaceutical Sciences, Utrecht University , 3584 CG Utrecht , The Netherlands.
Christina Tysoe
Lieke van GijzelDepartment of Chemical Biology and Drug Discovery , Utrecht Institute of Pharmaceutical Sciences, Utrecht University , 3584 CG Utrecht , The Netherlands.
Ryoji YoshisadaDepartment of Chemical Biology and Drug Discovery , Utrecht Institute of Pharmaceutical Sciences, Utrecht University , 3584 CG Utrecht , The Netherlands.
Mikael Trellet
Hugo van Ingen
Gary D Brayer
Alexandre M J J BonvinORCID 0000-0001-7369-1322
Seino A K JongkeesDepartment of Chemical Biology and Drug Discovery , Utrecht Institute of Pharmaceutical Sciences, Utrecht University , 3584 CG Utrecht , The Netherlands.ORCID 0000-0002-4796-0557
Utrecht University · NLUniversity of British Columbia · CA

Funding

X-ray Absorption Spectroscopy (XAS) pp.711-759P41GM103393 · NIGMS · STANFORD UNIVERSITY · PI HODGSON, KEITH O · 2012 to 2019
$30.6M
NIGMS NIH HHS P41 GM103393
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Catalytic DomainCrystallizationEnzyme InhibitorsHumansMolecular Docking SimulationPancreatic alpha-AmylasesPeptides, CyclicProtein BindingProtein ConformationProtein FoldingEnzyme InhibitorsPancreatic alpha-AmylasesPeptides, Cyclic

Identifiers

PMID31241898
PMCPMC6700688
OpenAlexW2955995626

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.