ArticleProceedings of the National Academy of Sciences of the United States of America2019
The purine biosynthesis regulator PurR moonlights as a virulence regulator in
Open access · bronzeAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 85 citations in OpenAlex.
- De novo or Salvage? Nucleotide Availability as a Driver of Bacterial Adaptation and Virulence.MicrobiologyOpen · 2026Review
- Cutibacterium acnes inhibits Staphylococcus lugdunensis biofilm formation through inhibition of autolysis and purine biosynthesis.NPJ biofilms and microbiomes · 2026Article
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- A requirement formSphere · 2026Article
- Global response to antibiotic exposure reveals a critical role for nucleotide metabolism in high-level β-lactam tolerance.npj antimicrobials and resistance · 2026Article
- Cutibacterium acnes inhibits Staphylococcus lugdunensis biofilm formation through inhibition of autolysis and purine biosynthesis.Research square · 2026Article
- Article
- Fermentative growth decreases the iron demand of Staphylococcus aureus.Journal of inorganic biochemistry · 2026Article
- Intracellular glutamine fluctuates with nitrogen availability and regulatesJournal of bacteriology · 2025Article
- Article
- Global response to antibiotic exposure uncovers a critical role for nucleotide metabolism in high-level β-lactam tolerance.Research square · 2025Article
- Pathoadapative Genomic Determinants ofMicroorganisms · 2025Article
- Pyrimidine sufficiency is required for Sae two-component system signaling inJournal of bacteriology · 2025Article
- Simulated exposures of oritavancin in in vitro pharmacodynamic models select for methicillin-resistant Staphylococcus aureus with reduced susceptibility to oritavancin but minimal cross-resistance or seesaw effect with other antimicrobials.The Journal of antimicrobial chemotherapy · 2025Article
- Genome-wide analysis of fitness determinants of Staphylococcus aureus during growth in milk.PLoS pathogens · 2025Article
- Microbiota-derived succinate promotes enterohaemorrhagic Escherichia coli virulence via lysine succinylation.Nature microbiology · 2025Article
- The PurR family transcriptional regulator promotes butenyl-spinosyn production in Saccharopolyspora pogona.Applied microbiology and biotechnology · 2025Article
- Integrated genomic and proteomic analysis of the mouse-adaptedCurrent research in microbial sciences · 2025Article
- Revealing fitness and virulence determinants of hypervirulentFrontiers in cellular and infection microbiology · 2025Article
- Vibrio cholerae virulence is blocked by chitosan oligosaccharide-mediated inhibition of ChsR activity.Nature microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
William E SauseDepartment of Microbiology, New York University School of Medicine, New York, NY 10016.
Divya BalasubramanianDepartment of Microbiology, New York University School of Medicine, New York, NY 10016.
Irnov IrnovDepartment of Microbiology, New York University School of Medicine, New York, NY 10016.
Richard CopinDepartment of Microbiology, New York University School of Medicine, New York, NY 10016.
Mitchell J SullivanDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Alexis SommerfieldDepartment of Microbiology, New York University School of Medicine, New York, NY 10016.
Rita ChanDepartment of Microbiology, New York University School of Medicine, New York, NY 10016.
Avantika DhabariaProteomics Laboratory, New York University School of Medicine, New York, NY 10016.
Manor AskenaziDepartment of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY 10016.
Beatrix UeberheideProteomics Laboratory, New York University School of Medicine, New York, NY 10016.
Bo ShopsinDepartment of Microbiology, New York University School of Medicine, New York, NY 10016.
Harm van BakelDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Victor J TorresDepartment of Microbiology, New York University School of Medicine, New York, NY 10016; victor.torres@nyulangone.org.
New York University · USIcahn School of Medicine at Mount Sinai · US
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ADRIANA HEGUY · 1985 to 2026
$83.1MINFECTIOUS DISEASES &BASIC MICROBIOLOGICAL MECHANISMST32AI007180 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI WEISER, JEFFREY NEAL · 1985 to 2022
$8.9MMechanistic Studies Of The Staphylococcus aureus LukAB CytotoxinR01AI099394 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Victor J. Torres · 2013 to 2026
$6.1MContribution of LukED to Staphylococcus aureus pathobiologyR01AI105129 · NIAID · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI TORRES, VICTOR J. · 2014 to 2023
$4.9MInvestigating genomic factors and microbiome features that impact CDI transmission and prognosisR01AI119145 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BASHIR, ALI M, VAN BAKEL, HARM · 2015 to 2019
$4.2MRole of precipitous virulence in invasiveness of community-acquired methicillin-rR01AI103268 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SHOPSIN, BO, TORRES, VICTOR J. · 2013 to 2017
$2.1MTransforming Genomics with 5 PB Big Omics Data Engine Cray CS300-AC SupercomputerS10OD018522 · OD · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KOVATCH, PATRICIA · 2014 to 2014
$1.9MNCI NIH HHS P30 CA016087NIAID NIH HHS R01 AI099394NIAID NIH HHS R01 AI103268NIAID NIH HHS R01 AI105129NIAID NIH HHS R01 AI119145NIAID NIH HHS T32 AI007180NIH HHS S10 OD018522
Abstract
The pathogen
Indexed as
Gene Expression Regulation, BacterialAnimalsBacterial ProteinsHumansMicePurinesRepressor ProteinsStaphylococcal InfectionsStaphylococcus aureusTranscription FactorsVirulence FactorsBacterial ProteinspurinePurinesPurR protein, BacteriaRepressor ProteinsTranscription FactorsVirulence FactorsinfectionMRSApathogenesispurine biosynthesisPurR
Identifiers
What OpenQuestion holds
Textmetadata
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Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.