ArticleFrontiers in plant science2019
Plant Proteases: From Key Enzymes in Germination to Allies for Fighting Human Gluten-Related Disorders.
Article in Frontiers in plant science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 58 citations in OpenAlex.
- Activity-Based Profiling of Papain-like Cysteine Proteases in Different Plant Organs During Barley Development.Plants (Basel, Switzerland) · 2026Article
- Review
- Activity-Based Profiling of Papain-like Cysteine Proteases During Late-Stage Leaf Senescence in Barley.Plants (Basel, Switzerland) · 2025Article
- Exploring Germination to Unlock the Nutritional Potential of Sorghum (Molecules (Basel, Switzerland) · 2025Article
- Endogenous Aβ and Exogenous Wheat Gluten Nanostructures: Understanding Peptide Self-Assembly in Disease.ACS nano · 2025Review
- Responses of α-amylase and protease activity to chemical agents and metallic salts in barley seeds (Heliyon · 2025Article
- Article
- Long-read sequencing reveals novel structural variation markers for key agronomic and quality traits of food-grade soybean.Frontiers in plant science · 2025Article
- Enhanced Oligopeptide and Free Tryptophan Release from Chickpea and Lentil Proteins: A Comparative Study of Enzymatic Modification with Bromelain, Ficin, and Papain.Plants (Basel, Switzerland) · 2024Article
- Role of Microbes in Alleviating Crop Drought Stress: A Review.Plants (Basel, Switzerland) · 2024Review
- Isolation and Evaluation of the Antagonistic Activity ofMicroorganisms · 2023Article
- Product safety aspects of plant molecular farming.Frontiers in bioengineering and biotechnology · 2023Review
- In order to lower the antinutritional activity of serine protease inhibitors, we need to understand their role in seed development.Frontiers in plant science · 2023Article
- Recombinant Cathepsin L ofInternational journal of molecular sciences · 2022Article
- Priming with copper-chitosan nanoparticles elicit tolerance against PEG-induced hyperosmotic stress and salinity in wheat.BMC chemistry · 2022Article
- Next-generation nutraceuticals: bioactive peptides from plant proteases.Biotechnologia · 2022Review
- Identification of Proteases and Protease Inhibitors in Seeds of the Recalcitrant Forest Tree SpeciesFrontiers in plant science · 2022Article
- Systems biology of resurrection plants.Cellular and molecular life sciences : CMLS · 2021Review
- Synergistic Effect of Enzyme Hydrolysis and Microwave Reactor Pretreatment as an Efficient Procedure for Gluten Content Reduction.Foods (Basel, Switzerland) · 2021Article
- New Insights into Non-Dietary Treatment in Celiac Disease: Emerging Therapeutic Options.Nutrients · 2021Review
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant proteases play a crucial role in many different biological processes along the plant life cycle. One of the most determinant stages in which proteases are key protagonists is the plant germination through the hydrolysis and mobilization of other proteins accumulated in seeds and cereal grains. The most represented proteases in charge of this are the cysteine proteases group, including the C1A family known as papain-like and the C13 family also called legumains. In cereal species such as wheat, oat or rye, gluten is a very complex mixture of grain storage proteins, which may affect the health of sensitive consumers like celiac patients. Since gluten proteins are suitable targets for plant proteases, the knowledge of the proteases involved in storage protein mobilization could be employed to manipulate the amount of gluten in the grain. Some proteases have been previously found to exhibit promising properties for their application in the degradation of known toxic peptides from gluten. To explore the variability in gluten-degrading capacities, we have now analyzed the degradation of gluten from different wheat cultivars using several cysteine proteases from barley. The wide variability showed highlights the possibility to select the protease with the highest potential to alter grain composition reducing the gluten content. Consequently, new avenues could be explored combining genetic manipulation of proteolytic processes with silencing techniques to be used as biotechnological tools against gluten-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.