Evidence map›Paper›PMID 31178862›Full record

ReviewFrontiers in immunology2019

Long Chain Polyunsaturated Fatty Acids (LCPUFAs) in the Prevention of Food Allergy.

Tamara Hoppenbrouwers, Jelena H Cvejić Hogervorst, Johan Garssen, Harry J Wichers, Linette E M Willemsen

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Effects of pre- and postnatal probiotic and ω-3 fatty acid supplementation on cytokine and chemokine responses to allergens and TLR ligands during infancy.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
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  8. Age-specific Metabolomic profiles in children with food allergy.Clinical immunology (Orlando, Fla.) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Tamara HoppenbrouwersFood Quality and Design, Wageningen University & Research, Wageningen, Netherlands.
Jelena H Cvejić HogervorstDepartment of Pharmacy, Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia.
Johan GarssenDepartment of Immunology, Nutricia Research BV, Utrecht, Netherlands.
Harry J WichersFood & Biobased Research, Wageningen University & Research, Wageningen, Netherlands.
Linette E M WillemsenDivision of Pharmacology, Department of Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

N-3 long chain polyunsaturated fatty acids (LCPUFAs) are considered to possess protective properties for human health by impacting on immunological reactions. An "inflammation-suppressive" effect appears to be the common denominator of the beneficial effects of most of these dietary components which may protect against the development of chronic immune disorders such as (food) allergy. LCPUFAs, especially n-3 LCPUFAs, have been shown to interact with both the sensitization as well as the effector phase in food allergy in pre-clinical models. In this review, we explore the anti-allergic properties of LCPUFAs by providing an overview of clinical,

Indexed as

AllergensAnimalsDietary Fats, UnsaturatedDietary SupplementsFood HypersensitivityHumansImmunizationImmunomodulationLipid PeroxidationAllergensDietary Fats, Unsaturatedanti-inflammatoryfood allergyimmune responseLCPUFAPUFA

Identifiers

PMID31178862
PMCPMC6538765

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.