ArticleSmall (Weinheim an der Bergstrasse, Germany)2019
Highly Porous Microcarriers for Minimally Invasive In Situ Skeletal Muscle Cell Delivery.
Article in Small (Weinheim an der Bergstrasse, Germany), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it, 147 citations in OpenAlex.
- Vascularised organoids: Recent advances and applications in cancer research.Clinical and translational medicine · 2025Pooled it
- Injectable chondroitin sulfate-glycosylated decellularized extracellular matrix microgels activate Wnt/β-Catenin signaling to promote functional muscle regeneration in VML.Bioactive materials · 2026Article
- Transwell membrane material affects myogenic differentiation in human primary myoblast-adipocyte co-culture.Physiological reports · 2026Article
- Freeze-Derived Microporous Biomaterials for Tissue Engineering Applications.Smart medicine · 2026Review
- Mossy-textured hydroxyapatite-modified poly (lactic-co-glycolic acid) microspheres promote collagen regeneration via calcium/TGF-β and chemokine signaling pathways in soft tissue augmentation.Bioactive materials · 2026Article
- Microgel-Based Hierarchical Porous Hydrogel Patch with Adhesion and Resilience for Myocardial Infarction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Preparation and Research Progress of Polymer-Based Anion Exchange Chromatography Stationary Phases.Polymers · 2026Review
- Evaluation of 3D biomimetic microcarriers for enhancing therapeutic efficacy of human umbilical cord mesenchymal stem cells in psoriasis treatment.Frontiers in immunology · 2026Article
- Trends in non-animal scaffolds for cultured meat structuration.NPJ science of food · 2025Review
- 3D-Printed Microfluidic Platform for Creating Porous Nanofibrous Microspheres to Regulate Cell Response and Enhance Tissue Regeneration.Small (Weinheim an der Bergstrasse, Germany) · 2025Article
- Alternative Techniques for Porous Microparticle Production: Electrospraying, Microfluidics, and Supercritical COPharmaceutical research · 2025Review
- Transdermal delivery of timolol maleate using hydrogel microneedles for the treatment of infantile haemangiomas.Materials today. Bio · 2025Article
- A View on the Synthesis and Characterization of Porous Microspheres Containing Pyrrolidone Units.Materials (Basel, Switzerland) · 2025Article
- Microfluidics-Based Microcarriers for Live-Cell Delivery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Freeze-Derived Anisotropic Porous Microparticles for Engineered Mesenchymal Stem Cell Loading and Wound Healing.Research (Washington, D.C.) · 2025Article
- Advancements in skeletal muscle tissue engineering: strategies for repair and regeneration of skeletal muscle beyond self-repair.Regenerative biomaterials · 2025Review
- Porous hydrogel microspheres with excellent temperature-sensitive, magnetic and fluorescent properties for drug delivery.RSC advances · 2024Article
- Granular Porous Nanofibrous Microspheres Enhance Cellular Infiltration for Diabetic Wound Healing.ACS nano · 2024Article
- A critical size volumetric muscle loss model in mouse masseter with impaired mastication on nutrition.Cell proliferation · 2024Article
- New dimensions of electrospun nanofiber material designs for biotechnological uses.Trends in biotechnology · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Microscale cell carriers have recently garnered enormous interest in repairing tissue defects by avoiding substantial open surgeries using implants for tissue regeneration. In this study, the highly open porous microspheres (HOPMs) are fabricated using a microfluidic technique for harboring proliferating skeletal myoblasts and evaluating their feasibility toward cell delivery application in situ. These biocompatible HOPMs with particle sizes of 280-370 µm possess open pores of 10-80 µm and interconnected paths. Such structure of the HOPMs conveniently provide a favorable microenvironment, where the cells are closely arranged in elongated shapes with the deposited extracellular matrix, facilitating cell adhesion and proliferation, as well as augmented myogenic differentiation. Furthermore, in vivo results in mice confirm improved cell retention and vascularization, as well as partial myoblast differentiation. These modular cell-laden microcarriers potentially allow for in situ tissue construction after minimally invasive delivery providing a convenient means for regeneration medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.