Evidence map›Paper›PMID 30999646›Full record

ArticleMolecules (Basel, Switzerland)2019

Novel C-2 Symmetric Molecules as α-Glucosidase and α-Amylase Inhibitors: Design, Synthesis, Kinetic Evaluation, Molecular Docking and Pharmacokinetics.

Danish Shahzad, Aamer Saeed, Fayaz Ali Larik, Pervaiz Ali Channar, Qamar Abbas, Mohamed F Alajmi, M Ifzan Arshad, Mauricio F Erben, Mubashir Hassan, Hussain Raza and 2 more

Abstract readEvaluation Study
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Review
  3. New 1RSC advances · 2025
    Article
  4. Article
  5. Review
  6. Article
  7. Synthesis of newHeliyon · 2024
    Article
  8. Article
  9. Identification and Isolation of α-Glucosidase Inhibitors fromInternational journal of molecular sciences · 2023
    Article
  10. Article
  11. Synthesis and bioactivities evaluation of oleanolic acid oxime ester derivatives asJournal of enzyme inhibition and medicinal chemistry · 2022
    Article
  12. Article
  13. Article
  14. Article
  15. Synthesis,Journal of enzyme inhibition and medicinal chemistry · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Danish ShahzadDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan. danish.scientist.shahzad@gmail.com.
Aamer SaeedDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan. aamersaeed@yahoo.com.ORCID 0000-0002-7112-9296
Fayaz Ali LarikDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan. fayazali@chem.qau.edu.pk.ORCID 0000-0002-8491-5229
Pervaiz Ali ChannarDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan. mrpervaiz@gmail.com.
Qamar AbbasDepartment of Physiology, University of Sindh, Jamshoro 76080, Pakistan. qamar.abbas.qau@gmail.com.
Mohamed F AlajmiDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia. malajmii@ksu.edu.sa.
M Ifzan ArshadDepartment of Chemistry, Quaid-I-Azam University, Islamabad 45320, Pakistan. ifzan_ifzan@yahoo.com.
Mauricio F ErbenCEQUINOR (UNLP, CONICET-CCT La Plata), Departamento de Química, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, Boulevard 120 e/60 y 64 N°1465, La Plata 1900, Argentina. erbenmf@gmail.com.ORCID 0000-0001-8467-2784
Mubashir HassanDepartment of Biological Sciences, College of Natural Sciences, Kongju National University, 56 Gongjudehak-Ro, Gongju, Chungnam 32588, Korea. mubashirhassan_gcul@yahoo.com.
Hussain RazaDepartment of Biological Sciences, College of Natural Sciences, Kongju National University, 56 Gongjudehak-Ro, Gongju, Chungnam 32588, Korea. hussain_solangi@yahoo.com.ORCID 0000-0002-3078-6660
Sung-Yum SeoDepartment of Biological Sciences, College of Natural Sciences, Kongju National University, 56 Gongjudehak-Ro, Gongju, Chungnam 32588, Korea. dnalove@kongju.ac.kr.ORCID 0000-0002-4211-524X
Hesham R El-SeediPharmacognosy Group, Department of Medicinal Chemistry, Biomedical Center (BMC), Uppsala University, SE-751 23 Uppsala, Sweden. Hesham.El-Seedi@fkog.uu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of symmetrical salicylaldehyde-bishydrazine azo molecules,

Indexed as

Glycoside Hydrolase InhibitorsMolecular Docking Simulationalpha-Amylasesalpha-GlucosidasesAnimalsMolecular StructureSwinealpha-Amylasesalpha-GlucosidasesGlycoside Hydrolase Inhibitorsantioxidantbis-azo Schiff baseschemo-informaticsdual inhibitorkinetic mechanismmolecular dockingSARα-amylaseα-glucosidase inhibitor

Identifiers

PMID30999646
PMCPMC6515238

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.