Evidence map›Paper›PMID 30906116›Full record

ArticleClinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association2017

Neurobiological Development in the Context of Childhood Trauma.

Dorthie Cross, Negar Fani, Abigail Powers, Bekh Bradley

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06945497 (School-based Practices in Arts and Resilience for Kids), which is not on this map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
11.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06945497 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

School-based Practices in Arts and Resilience for Kids (SPARK Study)

TypeinterventionalSponsorWayne State UniversityRan2025 to 2027Enrolled250ConditionsAnxiety, Posttraumatic Stress Disorder, TraumaArmsArt Therapy, Yoga/Mindfulness
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it, 179 citations in OpenAlex.

  1. Pooled it
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  8. Review
  9. Dissociative symptoms during the SARS-CoV-2 pandemic situation in mental health patients.Borderline personality disorder and emotion dysregulation · 2026
    Article
  10. Review
  11. Somatic symptoms and sensory dysregulation are central to the clinical presentation of PTSD.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2026
    Article
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Dorthie CrossDepartment of Psychology, Georgia Southern University.
Negar FaniDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine.
Abigail PowersDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine.
Bekh BradleyDepartment of Psychiatry and Behavioral Sciences, Emory University School of MedicineAtlanta VA Medical Center.
Emory University · USAtlanta VA Medical Center · USGeorgia Southern University · US

Funding

Genetic and Trauma-Related Risk Factors for PTSDR01MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2005 to 2014
$8.5M
Mechanisms of Intergenerational Impact of Maternal TraumaR01HD071982 · NICHD · EMORY UNIVERSITY · PI BRADLEY, BEKH · 2013 to 2017
$2.1M
Development, Trauma, and Genotype Effects on Biomarkers of Anxiety in ChildrenR01MH100122 · NIMH · EMORY UNIVERSITY · PI JOVANOVIC, TANJA · 2013 to 2017
$1.9M
Genetic and Trauma-Related Risk Factors for PTSD: From GWAS to FunctionR56MH071537 · NIMH · EMORY UNIVERSITY · PI RESSLER, KERRY J. · 2015 to 2015
$148k
The role of emotion dysregulation in PTSD symptomologyF32MH102890 · NIMH · EMORY UNIVERSITY · PI LOTT, ABIGAIL POWERS · 2014 to 2015
$102k
NICHD NIH HHS R01 HD071982NIMH NIH HHS F32 MH102890NIMH NIH HHS R01 MH071537NIMH NIH HHS R01 MH100122NIMH NIH HHS R56 MH071537
6 · The paper itself

Abstract

Neurobiological systems may be particularly susceptible to deleterious impact of childhood trauma, and the impact of childhood trauma on development and subsequent functional outcomes across the lifespan has been well-documented. The current review addresses the neurobiological impact of exposure to interpersonal trauma in childhood in the context of executive function, emotion regulation, and dissociation/interoceptive awareness. Subsequent risk for PTSD and depression is also discussed. The pathway of risk from childhood trauma to these cognitive, emotional, and psychiatric outcomes is addressed in terms of potential structural and functional alterations within the hippocampus, prefrontal cortex, and amygdala resulting from chronic or repeated activation of the hypothalamic-pituitary-adrenal (HPA) axis and its interaction with and influence on genetic and epigenetic processes during sensitive periods of development. Implications for practice are discussed.

Indexed as

childhood maltreatmentchildhood traumadissociationemotion regulationexecutive functionneurobiology

Identifiers

PMID30906116
PMCPMC6428430
OpenAlexW2617029690

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.