TrialJAMA network open2019

Assessment of Vascular Event Prevention and Cognitive Function Among Older Adults With Preexisting Vascular Disease or Diabetes: A Secondary Analysis of 3 Randomized Clinical Trials.

Alison Offer et al.PubMed ↗Full text ↗Publisher ↗

A secondary analysis of NCT00461630. The trial’s primary report, PMID 25014686, speaks for it on the map; the numbers here are shown and do not vote.

What the trial testedas reported · 1,197 people · 2019

Not counted

Reduced cardiovascular events

−0.15−0.19 to −0.11

As reported

difference −0.15, 95% CI −0.19 to −0.11

Range includes no effect

No clear effect on quality of life & behaviour

Doesn’t vote: a later paper about the trial

+0.35−0.37 to +1.06

As reported

difference 0.35, 95% CI −0.37 to 1.06

Two numbers in the abstract

the abstract, start to end

… expected reduction in cognitive aging of 0.15 (95% CI, 0.11-0.19) years.

… assessment) was a difference of 0.35 (95% CI, -0.37 to 1.06; …

← favours treatmentfavours comparator →

could be chance

Cardiovascular events

−0.15−0.19 to −0.11

Quality of life & behaviour

0.35−0.37 to 1.06

StatinsCardiovascular eventsQuality of life & behaviour

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12 papers cite it

2019

2020

2021

2022

2023

2024

2025

this papertrialcites it

The trial

NCT00461630phase 325,673 enrolled2007a later paper about it