ArticleEuropean journal of nutrition2020
Consumption of out-of-season orange modulates fat accumulation, morphology and gene expression in the adipose tissue of Fischer 344 rats.
Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 19 citations in OpenAlex.
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- Photoperiod-Dependent Effects on Blood Biochemical Markers of Phenolic-Enriched Fruit Extracts.Journal of agricultural and food chemistry · 2024Article
- The Phytoneuroendocrine System: Connecting Plants to Human Systems Biology.Integrative medicine (Encinitas, Calif.) · 2024Review
- Photoperiodic Remodeling of Adiposity and Energy Metabolism in Non-Human Mammals.International journal of molecular sciences · 2023Review
- In-Season Consumption of Locally Produced Tomatoes Decreases Cardiovascular Risk Indices.Nutrients · 2022Article
- Do You Have Problems When Reproducing Bioactivities of Food or Food Components? The Importance of Biological Rhythms.Nutrients · 2022Article
- Cardioprotective Properties of Phenolic Compounds: A Role for Biological Rhythms.Molecular nutrition & food research · 2022Review
- Time-of-day dependent effect of proanthocyanidins on adipose tissue metabolism in rats with diet-induced obesity.International journal of obesity (2005) · 2022Article
- Proanthocyanidins Restore the Metabolic Diurnal Rhythm of Subcutaneous White Adipose Tissue According to Time-Of-Day Consumption.Nutrients · 2022Article
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- Chrononutrition and Polyphenols: Roles and Diseases.Nutrients · 2019Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
purposeAccording to the xenohormesis theory, animals receive signals from plants that give clues about the changing environment, and thus, depending on the season of the year, animals develop physiological changes to adapt in advance to the seasonal changes. Our objective was to study how the same fruit cultivated during two different seasons could affect the adipose tissue of rats.
methodsThirty-six Fischer 344 rats were acclimated for 4 weeks to long-day or short-day (SD) photoperiods. After adaptation, three groups (n = 6) from each photoperiod were supplemented either with orange from the northern (ON) or southern (OS) hemispheres harvested in the same month or a vehicle (VH) for 10 weeks. Biometric measurements, postprandial plasmatic parameters, gene expression of the inguinal white adipose tissue (IWAT) and brown adipose tissue (BAT), and the histology of the IWAT were analysed.
resultsThe OSSD group increased its fat content compared to the VHSD, while the ON groups showed no biometric differences. The OS groups were further studied, and the IWAT showed increased levels of Pparγ gene expression and a higher percentage of larger adipocytes compared to the VH group. The BAT showed down-regulation of Lpl, Cpt1b and Pparα in the OSSD group compared to that in the VHSD group, suggesting an inhibition of BAT activity, however, Ucp1 gene expression was up-regulated.
conclusionsWe observed a different effect from both fruits, with the OS promoting a phenotype prone to fat accumulation when consumed in an SD photoperiod, which might be explained by the xenohormesis theory.
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