Evidence map›Paper›PMID 30650530›Full record

ReviewNutrients2019

Gluten-Free Diet: Gaps and Needs for a Healthier Diet.

Valentina Melini, Francesca Melini

Registry-linked trialAbstract readReview
In one paragraph

Review in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05530070 (Cardiovascular Risk Factors in Coeliac Disease), which is not on this map. Cited by 129 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
129citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05530070 narecruitingnot on this mapstarted 2022, after this paper: background citation

Cardiovascular Risk Factors in Coeliac Disease: a Series of Studies

TypeinterventionalSponsorUniversity of PecsRan2022 to 2026Enrolled190ConditionsCoeliac DiseaseArmsDietary intervention, Standard of care, Cardiovascular risk-related parameters
3 · Its place in the literature

Who cites it

129 citing papers in PubMed, 9 syntheses or guidelines pooled it.

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69 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Valentina MeliniCREA Research Centre for Food and Nutrition; Via Ardeatina 546, I-00178 Rome, Italy. valentina.melini@crea.gov.it.ORCID 0000-0001-9071-5680
Francesca MeliniCREA Research Centre for Food and Nutrition; Via Ardeatina 546, I-00178 Rome, Italy. francesca.melini@crea.gov.it.ORCID 0000-0003-3159-2646

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The gluten-free diet (GFD) is currently the only effective treatment in remitting the symptoms of coeliac disease (CD), a chronic systemic autoimmune disorder caused by a permanent intolerance to gluten proteins in genetically susceptible individuals. The diet entails the substitution of gluten-containing products with gluten-free-rendered products. However, over recent decades the nutritional profile of gluten-free (GF) food products has been increasingly questioned within the scientific community. The aim of this paper is to review the nutritional profile of gluten-free-rendered products currently available on the market, and discuss the possible relationship thereof with the nutritional status of coeliac patients on a GFD. Key inadequacies of currently available GF products are low protein content and a high fat and salt content. More adequate levels of dietary fiber and sugar than in the past have been reported. Population studies confirmed the above mentioned inadequacies. Further efforts are required to conceive adoptable interventions for product development and reformulation in order to achieve compliance with nutritional recommendations.

Indexed as

Diet, Gluten-FreeNutritional RequirementsNutritive ValueCeliac DiseaseDiet, HealthyGlutensHumansGlutenscoeliac diseasegluten-free dietgluten-free diet co-morbiditiesgut microbiotametabolic syndromenutritional adequacyobesity

Identifiers

PMID30650530
PMCPMC6357014

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.