Evidence map›Paper›PMID 30531917›Full record

ReviewNature reviews. Endocrinology2019

Circadian clocks and insulin resistance.

Dirk Jan Stenvers, Frank A J L Scheer, Patrick Schrauwen, Susanne E la Fleur, Andries Kalsbeek

Registry-linked trialOpen access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05314855 (Role of the Central Brain Clock in the Pathophysiology of Insulin Resistance), which is not on this map. Cited by 369 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
369citing papers in PubMed, 5 pooled it
22.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05314855 completednot on this mapstarted 2023, after this paper: background citation

Role of the Central Brain Clock in the Pathophysiology of Insulin Resistance

Typeobservational_patient_registrySponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Ran2023 to 2025Enrolled28ConditionsInsulin Resistance, Type 2 DiabetesArmsfunctional MRI
3 · Its place in the literature

Who cites it

369 citing papers in PubMed, 5 syntheses or guidelines pooled it, 684 citations in OpenAlex.

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  11. Circadian Modulation of the Antioxidant Effect of Grape Consumption: A Randomized Controlled Trial.International journal of environmental research and public health · 2023
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309 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 2 countries.

Dirk Jan StenversDepartment of Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.ORCID http://orcid.org/0000-0002-9519-5140
Frank A J L ScheerDivision of Sleep Medicine, Harvard Medical School, Boston, MA, USA.
Patrick SchrauwenDepartment of Nutrition and Movement Sciences, NUTRIM, School for Nutrition and Translational Research in Metabolism, Maastricht University Medical Center, Maastricht, Netherlands.
Susanne E la FleurDepartment of Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Andries KalsbeekDepartment of Endocrinology and Metabolism, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands. a.kalsbeek@nin.knaw.nl.ORCID http://orcid.org/0000-0001-9606-8453
Amsterdam University Medical Centers · NLBrigham and Women's Hospital · USMaastricht University · NLNetherlands Institute for Neuroscience · NLRoyal Netherlands Academy of Arts and Sciences · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Insulin resistance is a main determinant in the development of type 2 diabetes mellitus and a major cause of morbidity and mortality. The circadian timing system consists of a central brain clock in the hypothalamic suprachiasmatic nucleus and various peripheral tissue clocks. The circadian timing system is responsible for the coordination of many daily processes, including the daily rhythm in human glucose metabolism. The central clock regulates food intake, energy expenditure and whole-body insulin sensitivity, and these actions are further fine-tuned by local peripheral clocks. For instance, the peripheral clock in the gut regulates glucose absorption, peripheral clocks in muscle, adipose tissue and liver regulate local insulin sensitivity, and the peripheral clock in the pancreas regulates insulin secretion. Misalignment between different components of the circadian timing system and daily rhythms of sleep-wake behaviour or food intake as a result of genetic, environmental or behavioural factors might be an important contributor to the development of insulin resistance. Specifically, clock gene mutations, exposure to artificial light-dark cycles, disturbed sleep, shift work and social jet lag are factors that might contribute to circadian disruption. Here, we review the physiological links between circadian clocks, glucose metabolism and insulin sensitivity, and present current evidence for a relationship between circadian disruption and insulin resistance. We conclude by proposing several strategies that aim to use chronobiological knowledge to improve human metabolic health.

Indexed as

Insulin ResistanceAnimalsBlood GlucoseCircadian ClocksCircadian RhythmDiabetes Mellitus, Type 2Drug Administration ScheduleEatingEnergy MetabolismGlucoseHumansInsulinMiceBlood GlucoseGlucoseInsulin

Identifiers

PMID30531917
OpenAlexW2905294359

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.