Evidence map›Paper›PMID 30442967›Full record

ArticleScientific reports2018

Insights into the Chemistry of Non-Enzymatic Browning Reactions in Different Ribose-Amino Acid Model Systems.

Daniel Hemmler, Chloé Roullier-Gall, James W Marshall, Michael Rychlik, Andrew J Taylor, Philippe Schmitt-Kopplin

Abstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed.

  1. Article
  2. Article
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  4. Article
  5. Article
  6. Formation of Aroma Characteristics in RoastedFoods (Basel, Switzerland) · 2025
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Effect of Amino Acid, Sugar, CaMolecules (Basel, Switzerland) · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Daniel HemmlerComprehensive Foodomics Platform, Analytical Food Chemistry, Technical University Munich, Alte Akademie 10, 85354, Freising, Germany. daniel.hemmler@tum.de.ORCID http://orcid.org/0000-0003-2540-0054
Chloé Roullier-GallComprehensive Foodomics Platform, Analytical Food Chemistry, Technical University Munich, Alte Akademie 10, 85354, Freising, Germany.
James W MarshallThe Waltham Centre for Pet Nutrition, Mars Petcare UK, Waltham-on-the-Wolds, Leicestershire, LE14 4RT, United Kingdom.
Michael RychlikComprehensive Foodomics Platform, Analytical Food Chemistry, Technical University Munich, Alte Akademie 10, 85354, Freising, Germany.
Andrew J TaylorThe Waltham Centre for Pet Nutrition, Mars Petcare UK, Waltham-on-the-Wolds, Leicestershire, LE14 4RT, United Kingdom.
Philippe Schmitt-KopplinComprehensive Foodomics Platform, Analytical Food Chemistry, Technical University Munich, Alte Akademie 10, 85354, Freising, Germany. schmitt-kopplin@helmholtz-muenchen.de.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactions between sugars and amino acids in the Maillard reaction produce a multitude of compounds through interconnected chemical pathways. The course of the pathways changes depending on the nature of the amino acids and sugars as well as the processing conditions (e.g. temperature, water activity). Some partial pathways have been elucidated using labelled precursors but the process is very time intensive. Here, we use rapid, non-targeted analysis with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR-MS) to deliver the molecular formulae and ion intensities of the compounds generated from reaction of four amino acids with ribose (10 h at 100 °C) to study the effect of amino acid side chains on the reaction pathways. Using van Krevelen diagrams, known chemical changes during the reaction (e.g. dehydration or decarboxylation) can be studied. Comparison of the data from the four amino acids studied, showed a common pathway, which involved 73 Maillard reaction products (MRPs) where the differences were due only to the nature of the amino acid side chain. From the more than 1400 different molecular formulae found, pathways unique to the amino acids were also identified and the order of reactivity was lysine >cysteine >isoleucine ≈ glycine. While unequivocal identification of the compounds cannot be achieved with FT-ICR-MS, applying known chemical transformations found in the Maillard reaction, not only identifies new and known pathways, but also integrates the MRPs into a general Maillard reaction scheme that better represents the totality of the Maillard reaction.

Indexed as

Maillard ReactionModels, ChemicalAminesAmino AcidsCarbonGlycation End Products, AdvancedRiboseTime FactorsUltraviolet RaysAminesAmino AcidsCarbonGlycation End Products, AdvancedRibose

Identifiers

PMID30442967
PMCPMC6237888

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.