ArticleOxidative medicine and cellular longevity2018
Rosemary Reduces Heat Stress by Inducing CRYAB and HSP70 Expression in Broiler Chickens.
Article in Oxidative medicine and cellular longevity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 67 citations in OpenAlex.
- Functional effects of rosmarinic acid on gut health and epigenetic regulation in antibiotic-free poultry diets.Poultry science · 2026Review
- Characterization of oxidative status in maize protoplasts under temperature and saline-alkali stresses.BMC plant biology · 2026Article
- Quercetagetin Ameliorates Heat Stress-Induced Intestinal Damage via Oxidative Stress, Inflammation and Gut Microbiota in Mice.Microorganisms · 2026Article
- Supplementation of Rosemary Extract Improves Lactation Performance and Rumen Function in Dairy Buffaloes Under Hot Weather.Animals : an open access journal from MDPI · 2026Article
- Heat shock proteins in farmed aquatic animals: advancing animal health and welfare management through building resilience.Frontiers in immunology · 2026Review
- Rosemary powder as a natural supplement to mitigate mortality in broilers under heat stress.Open veterinary journal · 2025Article
- Alleviation of lipopolysaccharide-induced heart inflammation in poultry treated with carnosic acid via the NF-κB and MAPK pathways.Journal of animal science · 2025Article
- Effect of areca nut extracts on growth performance, slaughtering performance, and meat quality of broiler chickens.Frontiers in veterinary science · 2025Article
- HSP90 Enhances Mitophagy to Improve the Resistance of Car-Diomyocytes to Heat Stress in Wenchang Chickens.International journal of molecular sciences · 2024Article
- Effects of medical plants on alleviating the effects of heat stress on chickens.Poultry science · 2024Review
- Physalis Calyx seu Fructus relieves chicken intestinal damage to heat via improving the antioxidant ability.Frontiers in immunology · 2024Article
- Transcriptome analysis of multiple tissues reveals the potential mechanism of death under acute heat stress in chicken.BMC genomics · 2023Article
- An evaluation of the thermoregulatory potential of in ovo delivered bioactive substances (probiotic, folic acid, and essential oil) in broiler chickens.Poultry science · 2023Article
- Bacillus pumilus TS1 alleviates Salmonella Enteritidis-induced intestinal injury in broilers.BMC veterinary research · 2023Article
- Mitigation of heat stress effects on laying hens' performances, egg quality, and some blood parameters by adding dietary zinc-enriched yeasts, parsley, and their combination.Frontiers in veterinary science · 2023Article
- Effects of in ovo feeding of chlorogenic acid on antioxidant capacity of postnatal broilers.Frontiers in physiology · 2023Article
- The Effects of Heat Stress on the Transcriptome of Human Cancer Cells: A Meta-Analysis.Cancers · 2022Review
- Evaluation of Rosmarinic Acid on Broiler Growth Performance, Serum Biochemistry, Liver Antioxidant Activity, and Muscle Tissue Composition.Animals : an open access journal from MDPI · 2022Article
- Preliminary Investigation of the Effects of Rosemary Extract Supplementation on Milk Production and Rumen Fermentation in High-Producing Dairy Cows.Antioxidants (Basel, Switzerland) · 2022Article
- Overexpression of Heat Shock Protein 70 Ameliorates Meat Quality of Broilers Subjected to Pre-Slaughter Transport at High Ambient Temperatures by Improving Energy Status of Pectoralis Major Muscle and Antioxidant Capacity.Antioxidants (Basel, Switzerland) · 2022Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat stress negatively affects poultry production and animal health. In response, animals invoke a heat stress response by inducing heat shock proteins (HSPs). Scientists are actively seeking natural products that can enhance the heat shock response. The present study aimed at assessing the effects of a purified rosemary extract comprising antioxidant compounds on the heat shock response and HSP expression profile in broiler chickens. The response of broilers to HS in the presence of purified rosemary extract was assessed using an in vivo myocardial cell model. Pathological lesions of heart tissue were examined microscopically. The levels and activities of enzymes associated with heart damage and oxidative damage were detected. Immunohistochemical staining was performed for HSPs in myocardial cells. The results showed that lactate dehydrogenase (LDH), creatine kinase (CK), and myocardial CK (CKMB) levels were reduced by the purified rosemary extract before and during heat stress. Heat stress alone increased CK and CKMB levels. The levels of oxidative damage-associated enzymes were compared between the rosemary + heat stress and heat stress-alone groups. The results indicated that in terms of these enzymes, the purified rosemary extract induced a more antioxidative state. Pathological examinations showed that heat stress caused myocardial fiber fracture, karyopyknosis, and degeneration. The addition of purified rosemary extract ameliorated these lesions to some degree, preserving more of the basic structure. Heat stress decreased the cellular levels of crystallin alpha B (CRYAB) and HSP70. The addition of the purified rosemary extract significantly increased the levels of CRYAB and HSP70 during heat stress (
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