Evidence map›Paper›PMID 30404222›Full record

ReviewMaterials (Basel, Switzerland)2018

An Introduction to 3D Bioprinting: Possibilities, Challenges and Future Aspects.

Željka P Kačarević, Patrick M Rider, Said Alkildani, Sujith Retnasingh, Ralf Smeets, Ole Jung, Zrinka Ivanišević, Mike Barbeck

Abstract readReview
In one paragraph

Review in Materials (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers.

0numbers the graph read from it
0cells of the map it votes in
167citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

167 citing papers in PubMed.

  1. Article
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  4. Nano-Based 3D Printed Scaffold for Bone Tissue Engineering.Bioengineering (Basel, Switzerland) · 2026
    Review
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  7. Cancer metastasisFrontiers in bioengineering and biotechnology · 2026
    Review
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  13. Article
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107 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Željka P KačarevićDepartment of Anatomy Histology, Embryology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health, University of Osijek, 31000 Osijek, Croatia. zeljkapericc@gmail.com.ORCID 0000-0002-8250-723X
Patrick M RiderBotiss Biomaterials, Hauptstraße 28, 15806 Zossen, Germany. patrick.rider@botiss.com.ORCID 0000-0002-3620-7199
Said AlkildaniDepartment of Biomedical Engineering, Faculty of Applied Medical Sciences, German-Jordanian University, 11180 Amman, Jordan. saidkildani@gmail.com.ORCID 0000-0002-2629-4102
Sujith RetnasinghInstitute for Environmental Toxicology, Martin-Luther-Universität, Halle-Wittenberg and Faculty of Biomedical Engineering, Anhalt University of Applied Science, 06366 Köthen, Germany. sujiroshi@gmail.com.
Ralf SmeetsDepartment of Oral and Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, 20246 Hamburg, Germany. r.smeets@uke.de.
Ole JungDepartment of Oral Maxillofacial Surgery, Division of Regenerative Orofacial Medicine, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. ol.jung@uke.de.
Zrinka IvaniševićDepartment of Dental Medicine, Faculty of Dental Medicine and Health, University of Osijek, 31000 Osijek, Croatia. zrinkaivan@gmail.com.
Mike BarbeckBotiss Biomaterials, Hauptstraße 28, 15806 Zossen, Germany. mike.barbeck@icloud.com.ORCID 0000-0002-3001-1347

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioprinting is an emerging field in regenerative medicine. Producing cell-laden, three-dimensional structures to mimic bodily tissues has an important role not only in tissue engineering, but also in drug delivery and cancer studies. Bioprinting can provide patient-specific spatial geometry, controlled microstructures and the positioning of different cell types for the fabrication of tissue engineering scaffolds. In this brief review, the different fabrication techniques: laser-based, extrusion-based and inkjet-based bioprinting, are defined, elaborated and compared. Advantages and challenges of each technique are addressed as well as the current research status of each technique towards various tissue types. Nozzle-based techniques, like inkjet and extrusion printing, and laser-based techniques, like stereolithography and laser-assisted bioprinting, are all capable of producing successful bioprinted scaffolds. These four techniques were found to have diverse effects on cell viability, resolution and print fidelity. Additionally, the choice of materials and their concentrations were also found to impact the printing characteristics. Each technique has demonstrated individual advantages and disadvantages with more recent research conduct involving multiple techniques to combine the advantages of each technique.

Indexed as

3D scaffoldsadditive manufacturingextrusioninkjetlaser-assistedrapid prototypingstereolithography

Identifiers

PMID30404222
PMCPMC6266989

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.