Evidence map›Paper›PMID 30301803›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Meiosis-specific recombinase Dmc1 is a potent inhibitor of the Srs2 antirecombinase.

J Brooks Crickard, Kyle Kaniecki, Youngho Kwon, Patrick Sung, Eric C Greene

Open access · bronzeAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 38 citations in OpenAlex.

  1. Mechanisms That Govern Recombinase Fidelity Control During Eukaryotic Homologous Recombination.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
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  8. Review
  9. Article
  10. Rad54 and Rdh54 prevent Srs2-mediated disruption of Rad51 presynaptic filaments.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Annual review of genetics · 2020
    Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

J Brooks CrickardDepartment of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032.
Kyle KanieckiDepartment of Genetics and Development, Columbia University, New York, NY 10032.
Youngho KwonDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520.
Patrick SungDepartment of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520.
Eric C GreeneDepartment of Biochemistry & Molecular Biophysics, Columbia University, New York, NY 10032; ecg2108@cumc.columbia.edu.
Columbia University · USYale University · US

Funding

Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI John A. Tainer · 2001 to 2026
$89.6M
YEAST DNA REPAIR GENES AND PROTEINS OF THE RAD52 GROUPR01ES007061 · NIEHS · YALE UNIVERSITY · PI Patrick Sung · 1995 to 2026
$9.4M
Protein purification instrumentation in support of single molecule studies of genome integrityR35GM118026 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENE, ERIC C · 2016 to 2025
$5.7M
Roles of the RecQ Helicases BLM and RECQ5 in Genome MaintenanceR01ES015632 · NIEHS · YALE UNIVERSITY · PI SUNG, PATRICK · 2007 to 2017
$3.9M
NCI NIH HHS P01 CA092584NIEHS NIH HHS R01 ES007061NIEHS NIH HHS R01 ES015632NIGMS NIH HHS R35 GM118026
6 · The paper itself

Abstract

Cross-over recombination products are a hallmark of meiosis because they are necessary for accurate chromosome segregation and they also allow for increased genetic diversity during sexual reproduction. However, cross-overs can also cause gross chromosomal rearrangements and are therefore normally down-regulated during mitotic growth. The mechanisms that enhance cross-over product formation upon entry into meiosis remain poorly understood. In

Indexed as

Adenosine TriphosphateCell Cycle ProteinsChromosome SegregationDNA-Binding ProteinsDNA HelicasesHomologous RecombinationMeiosisRecombinasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAdenosine TriphosphateCell Cycle ProteinsDMC1 protein, S cerevisiaeDNA-Binding ProteinsDNA HelicasesRecombinasesSaccharomyces cerevisiae ProteinsSRS2 protein, S cerevisiaeDmc1homologous recombinationmeiosisRad51Srs2

Identifiers

PMID30301803
PMCPMC6205449
OpenAlexW2896707196

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.