Evidence map›Paper›PMID 30270019›Full record

Trial reportJournal of diabetes and its complications2018

Glycemic, inflammatory and oxidative stress responses to different high-intensity training protocols in type 1 diabetes: A randomized clinical trial.

Juliano B Farinha, Thiago R Ramis, Alexandra F Vieira, Rodrigo C O Macedo, Josianne Rodrigues-Krause, Francesco P Boeno, Helena T Schroeder, Carlos Henrique Müller, Winston Boff, Maurício Krause and 2 more

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of diabetes and its complications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 34 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 3 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05478707 phase2recruitingstarted 2023, after this paper: background citation

Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

Ran2023Enrolled47Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus, Type 1, Endothelial DysfunctionArmsDulaglutide, Placebo
PMID 29310645PMID 24742660PMID 22732108PMID 27295427PMID 27436611PMID 27633186PMID 21610226PMID 9490243PMID 34339111PMID 34075130PMID 33259257PMID 33219433other papers from this trial
Open the trial in the graph
NCT04732611 naunknown statusnot on this mapstarted 2021, after this paper: background citation

Effects of Pilates Exercises Versus Walking on Mechanical and Vascular Variables of Individuals With Type 2 Diabetes Mellitus: Randomized Clinical Trial

TypeinterventionalSponsorFederal University of Rio Grande do SulRan2021 to 2022Enrolled60ConditionsDiabetes Mellitus, Type 2ArmsPilates exercises, Walking protocol
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
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  4. A Resistance Training Program on Patients with Liver Cirrhosis: A Randomized Clinical Trial.International journal of environmental research and public health · 2025
    Trial
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  19. A Role for Advanced Glycation End Products in Molecular Ageing.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Juliano B FarinhaSchool of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Brazil. Electronic address: gefex.ufrgs@gmail.com.
Thiago R RamisSchool of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Alexandra F VieiraSchool of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Rodrigo C O MacedoSchool of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Josianne Rodrigues-KrauseSchool of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Francesco P BoenoSchool of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Helena T SchroederDepartment of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Carlos Henrique MüllerDepartment of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Winston BoffInstitute for Children with Diabetes, Porto Alegre, Brazil.
Maurício KrauseDepartment of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Paulo Ivo H De BittencourtDepartment of Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Alvaro Reischak-OliveiraSchool of Physical Education, Physiotherapy and Dance, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Universidade Federal do Rio Grande do Sul · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo investigate the effects of high-intensity interval training (HIIT) and/or strength training (ST) on inflammatory, oxidative stress (OS) and glycemic parameters in type 1 diabetes (T1DM) patients.

methodsAfter a 4-week control period, volunteers were randomly assigned to 10-week HIIT, ST or ST + HIIT protocol, performed 3×/week. Blood biochemistry, anthropometric, strength and cardiopulmonary fitness variables were assessed. Outcomes were analyzed via generalized estimating equations (GEE), with Bonferroni post hoc analysis.

resultsST, HIIT and ST + HIIT improved glycemic (HbA

conclusionsSimilar benefits afforded by ST, HIIT or ST + HIIT in T1DM people are associated with enhanced antioxidant systems and glucose-related parameter, even in a few weeks. From a practical clinical perspective, the performance of ST + HIIT may be advised for additional benefits regarding insulin dosage reduction.

Indexed as

High-Intensity Interval TrainingAdolescentAdultBlood GlucoseDiabetes Mellitus, Type 1Exercise TherapyFemaleHumansInflammationInfusions, SubcutaneousInsulinInsulin Infusion SystemsMaleOxidative StressResistance TrainingYoung AdultBlood GlucoseInsulinCytokinesHeat shock proteins 70High-intensity interval trainingInsulinReactive oxygen speciesResistance training

Identifiers

PMID30270019
OpenAlexW2891002903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.