Evidence map›Paper›PMID 30126204›Full record

ArticleMolecules (Basel, Switzerland)2018

Valorization of Olive Pomace-Based Nutraceuticals as Antioxidants in Chemical, Food, and Biological Models.

Dubravka Vitali Čepo, Kristina Radić, Sanja Jurmanović, Mario Jug, Marija Grdić Rajković, Sandra Pedisić, Tihomir Moslavac, Petra Albahari

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.4field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 48 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Dubravka Vitali ČepoFaculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia. dvitali@pharma.hr.
Kristina RadićFaculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia. kradic@pharma.hr.ORCID 0000-0001-5792-5061
Sanja JurmanovićFaculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia. sjurmanov@pharma.hr.
Mario JugFaculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia. mjug@pharma.hr.ORCID 0000-0001-5792-5061
Marija Grdić RajkovićFaculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia. mgrdic@pharma.hr.ORCID 0000-0001-5792-5061
Sandra PedisićDepartment of Food Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, Pijerottijeva 6, 10000, Zagreb, Croatia. spedisic@pbf.hr.
Tihomir MoslavacFaculty of Food Technology, University in Osijek, Franje Kuhača 20, 31000 Osijek, Croatia. tihomir.moslavac@ptfos.hr.
Petra AlbahariFaculty of Pharmacy and Biochemistry, University of Zagreb, Ante Kovačića 1, 10000 Zagreb, Croatia. saler_petra@yahoo.com.
University of Zagreb · HRUniversity of Osijek · HR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Waste remaining after the production of olive oil (olive pomace) is known to contain significant amounts of phenolic compounds that exert different types of biological activities, primarily acting as antioxidants. In this work, a sustainable approach that combines ultrasound-assisted extraction with food-grade solvents and encapsulation with different types of cyclodextrins was used to prepare olive pomace-based polyphenol rich extracts that were tested as antioxidants in various chemical, food, and biological model systems. Encapsulation with cyclodextrins had a significant positive impact on the chemical composition of obtained extracts and it positively affected their antioxidant activity. Observed effects can be explained by an increased content of polyphenols in the formulations, specific physical properties of encapsulated compounds improving their antioxidant activity in complex food/physiological environment, and enhanced interaction with natural substrates. Depending on the applied model, the tested samples showed significant antioxidant protection in the concentration range 0.1⁻3%. Among the investigated cyclodextrins, hydroxypropyl-β-cyclodextrin and randomly methylated-β-cyclodextrin encapsulated extracts showed particularly good antioxidant activity and were especially potent in oil-in-water emulsion systems (1242 mg/g and 1422 mg/g of Trolox equivalents, respectively), showing significantly higher antioxidant activity than Trolox (reference antioxidant). In other models, they provided antioxidant protection comparable to commonly used synthetic antioxidants at concentration levels of 2⁻3%.

Indexed as

Dietary SupplementsAntioxidantsChromatography, High Pressure LiquidFood AnalysisLipid PeroxidationOleaOlive OilPhenolsPhosphatidylethanolaminesPhytochemicalsPlant ExtractsPlant OilsSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryAntioxidantsdioleoyl phosphatidylethanolamineOlive OilPhenolsPhosphatidylethanolaminesPhytochemicalsPlant ExtractsPlant Oilsantioxidant activitycyclodextrin encapsulationinhibition of DNA scissionliposome modelmeat modelolive pomaceβ-carotene linoleate model

Identifiers

PMID30126204
PMCPMC6222651
OpenAlexW2885615088

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.