← GLP-1 receptor agonists × cardiovascular events

TrialDiabetes care2018

The Impact of Liraglutide on Diabetes-Related Foot Ulceration and Associated Complications in Patients With Type 2 Diabetes at High Risk for Cardiovascular Events: Results From the LEADER Trial.

Ketan Dhatariya et al.PubMed ↗Full text ↗Publisher ↗

A later paper about NCT01179048. The trial’s primary report, PMID 27295427, speaks for it on the map; the numbers here are shown and do not vote.

What the trial testedas reported · 2018

Range includes no effect

No clear effect on cardiovascular events

Doesn’t vote: a later paper about the trial

−8%−25% to +13%

Bigger than 1 in 10 for cardiovascular events

As reported

HR 0.92, 95% CI 0.75–1.13

One number in the abstract

the abstract, start to end

… respectively; hazard ratio [HR] 0.92 [95% CI 0.75, 1.13; …

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
HR 0.920.75–1.13
GLP-1 receptor agonistsCardiovascular events
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58 papers cite it

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this paperpooled ittrialcites it

The trial

Full record →Abstract, authors, funding and every citing paper · PMID 30072400