← SGLT2 inhibitors × cardiovascular events

SynthesisDiabetes, obesity & metabolism2018

Comparative effectiveness of canagliflozin, SGLT2 inhibitors and non-SGLT2 inhibitors on the risk of hospitalization for heart failure and amputation in patients with type 2 diabetes mellitus: A real-world meta-analysis of 4 observational databases (OBSERVE-4D).

Patrick B Ryan et al.PubMed ↗Full text ↗Publisher ↗

  • Canagliflozinlooks good hereLower HHF, no clear link with BKLE amputation.Correlation only, not a test of it.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

Canagliflozin went with lower HHF

−61%−74% to −40%

canagliflozin vs non-SGLT2i

Bigger than 9 in 10 for cardiovascular events

As reported

HR 0.39, 95% CI 0.26–0.60

Correlation · may be no link

No clear link with BKLE amputation

−25%−60% to +41%

canagliflozin vs non-SGLT2i

Bigger than 6 in 10 for cardiovascular events

As reported

HR 0.75, 95% CI 0.40–1.41

Correlation · may be no link

No clear link with BKLE amputation

+1%−7% to +10%

canagliflozin vs non-SGLT2i

Smaller than almost all for cardiovascular events

As reported

HR 1.01, 95% CI 0.93–1.10

Who was studied, and how

people with type 2 diabetes, in this paper

Already taking canagliflozin, or nottheir own situation, not assigned

on canagliflozin
not on SGLT2i

Canagliflozin went with lower HHF−61%

No clear link with BKLE amputation−25%

correlation, not a test

the abstract, start to end

… HHF with canagliflozin vs non-SGLT2i was 0.39 (95% CI, 0.26-0.60) in the …

… with canagliflozin vs non-SGLT2i was 0.75 (95% CI, 0.40-1.41) in the on-treatment analysis and 1.01 (95% CI, 0.93-1.10) in the …

← favours treatmentfavours comparator →
could be chance
HHFcanagliflozin vs non-SGLT2i
HR 0.390.26–0.60
BKLE amputationcanagliflozin vs non-SGLT2i
HR 0.750.40–1.41
BKLE amputationcanagliflozin vs non-SGLT2i
HR 1.010.93–1.10
SGLT2 inhibitorsCardiovascular events
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