Evidence map›Paper›PMID 29848836›Full record

Trial reportJournal of postgraduate medicine

Combination of arginine, glutamine, and omega-3 fatty acid supplements for perioperative enteral nutrition in surgical patients with gastric adenocarcinoma or gastrointestinal stromal tumor (GIST): A prospective, randomized, double-blind study.

C Ma, H Tsai, W Su, L Sun, Y Shih, J Wang

Registry-linked trialOpen access · diamondAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of postgraduate medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07506187 (The Role of Arginine in Oral Nutritional Supplementation in Preventing or Reducing Complications Following Colorectal Surgery in Patients Who Are Malnourished or at Risk of Malnutrition), which is not on this map. Cited by 28 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 8 pooled it
1.1field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07506187 nacompletednot on this map

The Role of Arginine in Oral Nutritional Supplementation in Preventing or Reducing Complications Following Colorectal Surgery in Patients Who Are Malnourished or at Risk of Malnutrition: A Randomized Controlled Trial

TypeinterventionalSponsorUniversity of CadizRan2022 to 2025Enrolled44ConditionsColorectal Cancer, Malnutrition or Risk of Malnutrition, Colorectal SurgeryArmsDiaba plus®: A high-protein, high-calorie ONS with no generic equivalent, Atémpero®: An ONS enriched with arginine with no generic equivalent
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 8 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  8. Effect of Perioperative Nutritional Supplementation on Postoperative Complications-Systematic Review and Meta-Analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

C MaDivision of Digestive and General Surgery, Department of Surgery, Kaohsiung Medical University Hospital; Graduate Institute of Clinical Medicine, College of Medicine; Division of Colorectal Surgery, Department of Surgery, Kaohsiung, Taiwan.
H TsaiDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital; Division of General Medicine Surgery, Department of Surgery; Department of Surgery, Faculty of Medicine, College of Medicine, Kaohsiung, Taiwan.
W SuDivision of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital; Division of General Medicine Surgery, Department of Surgery, Kaohsiung, Taiwan.
L SunNutrition Service Team, Kaohsiung Medical University Hospital; Department of Nursing, Kaohsiung, Taiwan.
Y ShihNutrition Service Team, Kaohsiung Medical University Hospital; Department of Nursing, Kaohsiung, Taiwan.
J WangGraduate Institute of Clinical Medicine, College of Medicine; Division of Colorectal Surgery, Department of Surgery, Kaohsiung Medical University Hospital; Department of Surgery, Faculty of Medicine, College of Medicine; Nutrition Service Team; Center for Biomarkers and Biotech Drugs; Research Center for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Kaohsiung Medical University Chung-Ho Memorial Hospital · TWGeneral Department of Preventive Medicine · VNInstitute of Clinical Research · USKaohsiung Medical University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Perioperative enteral nutrition (EN) enriched with immune-modulating substrates is preferable for patients undergoing major abdominal cancer surgery. In this study, perioperative EN enriched with immune-modulating nutrients such as arginine, glutamine, and omega-3 fatty acids was evaluated for its anti-inflammatory efficacy in patients with gastric adenocarcinoma or gastrointestinal stromal tumor (GIST) receiving curative surgery. Materials and Methods: This prospective, randomized, double-blind study recruited 34 patients with gastric adenocarcinoma or gastric GIST undergoing elective curative surgery. These patients were randomly assigned to the study group, receiving immune-modulating nutrient-enriched EN, or the control group, receiving standard EN from 3 days before surgery (preoperative day 3) to up to postoperative day 14 or discharge. Laboratory and inflammatory parameters were assessed on preoperative day 3 and postoperative day 14 or at discharge. Adverse events (AEs) and clinical outcomes were documented daily and compared between groups. Results: No significant differences were observed between the two groups in selected laboratory and inflammatory parameters, or in their net change, before and after treatment. AEs and clinical outcomes, including infectious complications, overall complications, time to first bowel action, and length of hospital stay after surgery, were comparable between treatment groups (all P > 0.05). Conclusion: Immune-modulating nutrient-enriched EN had no prominent immunomodulation effect compared with that of standard EN.

Indexed as

AdenocarcinomaAgedArginineDietary SupplementsDouble-Blind MethodEnteral NutritionFatty Acids, Omega-3FemaleGastrointestinal Stromal TumorsGlutamineHumansMaleMiddle AgedPerioperative CareProspective StudiesStomach NeoplasmsArginineFatty Acids, Omega-3GlutamineArgininegastric cancerglutamineimmune-modulating nutrientsomega-3 fatty acids

Identifiers

PMID29848836
PMCPMC6066627
OpenAlexW2806638746

What OpenQuestion holds

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LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.