Evidence map›Paper›PMID 29495317›Full record

ArticleNutrients2018

Spray-Dried Potato Juice as a Potential Functional Food Component with Gastrointestinal Protective Effects.

Małgorzata Kujawska, Anna Olejnik, Grażyna Lewandowicz, Przemysław Kowalczewski, Renata Forjasz, Jadwiga Jodynis-Liebert

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Postbiotic Potential of Heat-KilledJournal of microbiology and biotechnology · 2025
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  5. Comparative Evaluation ofFoods (Basel, Switzerland) · 2020
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  9. World journal of gastroenterology · 2019
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Małgorzata KujawskaDepartment of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznań, Poland. kujawska@ump.edu.pl.ORCID 0000-0002-5306-9904
Anna OlejnikDepartment of Biotechnology and Food Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego Str., 60-627 Poznań, Poland. aolejnik@up.poznan.pl.
Grażyna LewandowiczDepartment of Biotechnology and Food Microbiology, Poznan University of Life Sciences, 48 Wojska Polskiego Str., 60-627 Poznań, Poland. gralew@up.poznan.pl.
Przemysław KowalczewskiInstitute of Food Technology of Plant Origin, Poznan University of Life Sciences, 31 Wojska Polskiego Str., 60-624 Poznań, Poland. przemyslaw.kowalczewski@up.poznan.pl.ORCID 0000-0002-0153-4624
Renata ForjaszDepartment of Pharmacology, Poznan University of Medical Sciences, 5a Rokietnicka Str., 60-806 Poznań, Poland. rforjasz@ump.edu.pl.
Jadwiga Jodynis-LiebertDepartment of Toxicology, Poznan University of Medical Sciences, 30 Dojazd Str., 60-631 Poznań, Poland. liebert@ump.edu.pl.
Poznan University of Medical Sciences · PLUniversity of Life Sciences in Poznań · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeptic ulcer disease, including its complications and functional dyspepsia, are prevalent gastrointestinal diseases, etiopathogenesis of which is associated with mucosal inflammation. Research into new therapeutics capable of preventing or curing gastrointestinal mucosal damage has been steadily developing over past decades. This study was undertaken to evaluate whether a spray-dried preparation of potato juice is applicable for treating and preventing gastrointestinal mucosal damage.

methodsWe assessed potential protective effects of spray-dried potato juice (SDPJ) against gut inflammation in the co-culture Caco-2/RAW264.7 system, as well as a gastroprotective activity in a rat model of gastric ulceration.

resultsThe obtained results indicated that SDPJ down-regulates lipopolysaccharide (LPS)-induced mRNA expression and protein production of proinflammatory cytokines IL-6 and TNF-α in the co-culture model. Moreover, SDPJ provided dose-dependent protection against LPS-induced disruption of intestinal barrier integrity. In rats, five-day pretreatment with SDPJ in doses of 200 mg/kg and 500 mg/kg suppressed HCl/ethanol-induced TNF-α expression in gastric mucosa by 52% and 35%, respectively. In addition, the pretreatment with the lower dose of SDPJ reduced the incidence of ulcers (by 34%) expressed as ulcer index.

conclusionThe spray-dried potato juice appears to be an attractive candidate for ameliorating inflammation-related diseases of the gastrointestinal tract.

Indexed as

DesiccationAnimalsAnti-Ulcer AgentsCaco-2 CellsCell SurvivalFruit and Vegetable JuicesFunctional FoodGastric MucosaGastrointestinal TractHumansHydrogen-Ion ConcentrationInflammationInterleukin-6MaleMicePlant PreparationsAnti-Ulcer AgentsInterleukin-6Plant PreparationsTumor Necrosis Factor-alphaanti-inflammatory activityantiulcerogenic effectgastrointestinal protectionpotato juice

Identifiers

PMID29495317
PMCPMC5852835
OpenAlexW2793210696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.