Evidence map›Paper›PMID 29435599›Full record

ReviewArchives of microbiology2018

An overview of lectin-glycan interactions: a key event in initiating fungal infection and pathogenesis.

Suhas Ballal, Shashikala R Inamdar

Abstract readReview
PubMed Publisher
In one paragraph

Review in Archives of microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Investigation ofLife (Basel, Switzerland) · 2022
    Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Suhas BallalDepartment of Studies in Biochemistry, Karnatak University, Dharwad, India.
Shashikala R InamdarDepartment of Studies in Biochemistry, Karnatak University, Dharwad, India. srinamdar2009@gmail.com.
Karnatak University · IN

Funding

Department of Science and Technology, India SR/S0/BB-0085/2010/A /B
6 · The paper itself

Abstract

Infections due to microfungi are of serious concern in many parts of the world. Many species of microfungi are known to cause systemic infection in human beings. Pathogenic microorganisms employ various molecular strategies for colonizing a susceptible host. Recent studies have shown the importance of lectins from microfungi that enable the pathogen to interact with the host, resulting in host immune response. These fungal lectins or adhesins show specific affinities to the glycans present on the membrane proteins or lipids. Binding of the pathogen to the receptors, probably toll-like receptors or dectins, present on the host cell surface triggers/initiates a cascade of signalling pathways, leading to the activation of transcription factors such as NF-κB resulting in the release of proinflammatory cytokines which in turn recruit cells of the immune system to the site of microbial insult to combat the pathogen or resulting in pathogenesis. In this review, we will focus on the interaction between fungal lectins and the host glycans initiating pathogenesis and how the host immune system tries to suppress the pathogenesis.

Indexed as

AnimalsApoptosisCytokinesFungal ProteinsFungiHost-Pathogen InteractionsHumansImmunity, CellularLectinsMycosesPolysaccharidesSignal TransductionToll-Like ReceptorsCytokinesFungal ProteinsLectinsPolysaccharidesToll-Like ReceptorsFungal lectinsGlycan specificityImmunomodulationInterleukinsPathogenesisToll-like receptors

Identifiers

PMID29435599
OpenAlexW2793931934

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.