Evidence map›Paper›PMID 29089427›Full record

ArticlemBio2017

The Metallophore Staphylopine Enables

Kyle P Grim, Brian San Francisco, Jana N Radin, Erin B Brazel, Jessica L Kelliher, Paola K Párraga Solórzano, Philip C Kim, Christopher A McDevitt, Thomas E Kehl-Fie

Open access · goldAbstract read
In one paragraph

Article in mBio, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed
8.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 146 citations in OpenAlex.

  1. Pseudogenization of the cntQ permease confers distinct yersinopine-metal uptake selectivity in Yersinia species.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
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  2. Discovery ofmBio · 2026
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  7. D-alanine aminotransferase (Dat) promotesbioRxiv : the preprint server for biology · 2026
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  8. Metal-independent effects of calprotectin on cocultures ofbioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. Pseudopaline-mediated zinc uptake byInfection and immunity · 2026
    Article
  12. mSphere · 2026
    Article
  13. The innate immune protein calprotectin ablates the bactericidal activity of β-lactam antibiotics.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  14. Article
  15. Article
  16. Article
  17. Cryo-electron microscopy structure of a zinc uptake ABC transporter.bioRxiv : the preprint server for biology · 2025
    Article
  18. High-resolutionMicrobial genomics · 2025
    Article
  19. Article
  20. Article

48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 3 countries.

Kyle P GrimDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Brian San FranciscoInstitute for Genomic Biology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Jana N RadinDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Erin B BrazelResearch Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Jessica L KelliherDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Paola K Párraga SolórzanoDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Philip C KimDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Christopher A McDevittResearch Centre for Infectious Diseases, School of Biological Sciences, University of Adelaide, Adelaide, South Australia, Australia.
Thomas E Kehl-FieDepartment of Microbiology, University of Illinois Urbana-Champaign, Urbana, Illinois, USA kehlfie@illinois.edu.
University of Illinois Urbana-Champaign · USUniversity of Adelaide · AU

Funding

Overcoming nutritional immunity: Staphylococcal adaptation to host-imposed manganese and zinc starvationR01AI118880 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KEHL-FIE, THOMAS EVERETT · 2016 to 2020
$1.9M
Adaptation of Staphylococcus aureus to Mn and Zn starvation imposed by the hostK22AI104805 · NIAID · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI KEHL-FIE, THOMAS EVERETT · 2014 to 2015
$264k
NIAID NIH HHS K22 AI104805NIAID NIH HHS R01 AI118880
6 · The paper itself

Abstract

During infection, the host sequesters essential nutrients, such as zinc, to combat invading microbes. Despite the ability of the immune effector protein calprotectin to bind zinc with subpicomolar affinity,

Indexed as

Bacterial ProteinsGene Expression Regulation, BacterialHost-Pathogen InteractionsImidazolesLeukocyte L1 Antigen ComplexMembrane Transport ProteinsSiderophoresStaphylococcal InfectionsStaphylococcus aureusZincBacterial ProteinsImidazolesLeukocyte L1 Antigen ComplexMembrane Transport ProteinsSiderophoresstaphylopineZinccalprotectinCntABCDFnutritional immunitysiderophoresStaphylococcus aureusstaphylopinezinc

Identifiers

PMID29089427
PMCPMC5666155
OpenAlexW2767136855

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.