ArticleObesity (Silver Spring, Md.)2017
Proportional Feedback Control of Energy Intake During Obesity Pharmacotherapy.
Article in Obesity (Silver Spring, Md.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Long-Term Weight Loss With Metformin or Lifestyle Intervention in the Diabetes Prevention Program Outcomes Study.Annals of internal medicine · 2019Trial
- Insights into the neurobiology of weight loss after bariatric surgery and GLP-1R agonists.Neuropharmacology · 2025Review
- Physiology of the weight-loss plateau in response to diet restriction, GLP-1 receptor agonism, and bariatric surgery.Obesity (Silver Spring, Md.) · 2024Article
- Physiology of the Weight Loss Plateau after Calorie Restriction, GLP-1 Receptor Agonism, and Bariatric Surgery.bioRxiv : the preprint server for biology · 2023Article
- Energy homeostasis from Lavoisier to control theory.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Differential mechanisms affecting weight loss and weight loss maintenance.Nature metabolism · 2023Review
- A long-acting GDF15 analog causes robust, sustained weight loss and reduction of food intake in an obese nonhuman primate model.Clinical and translational science · 2023Article
- Energy intake as a short-term biomarker for weight loss in adults with obesity receiving liraglutide: A randomized trial.Obesity science & practice · 2021Article
- Describing the Weight-Reduced State: Physiology, Behavior, and Interventions.Obesity (Silver Spring, Md.) · 2021Article
- Impact of carbohydrates, fat and energy density on energy intake.Nature medicine · 2021Article
- The H2020 "NoHoW Project": A Position Statement on Behavioural Approaches to Longer-Term Weight Management.Obesity facts · 2021Article
- Health and Economic Impacts of the National Menu Calorie Labeling Law in the United States: A Microsimulation Study.Circulation. Cardiovascular quality and outcomes · 2020Article
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3 authors.
Funding
Abstract
objectiveObesity pharmacotherapies result in an exponential time course for energy intake whereby large early decreases dissipate over time. This pattern of declining drug efficacy to decrease energy intake results in a weight loss plateau within approximately 1 year. This study aimed to elucidate the physiology underlying the exponential decay of drug effects on energy intake.
methodsPlacebo-subtracted energy intake time courses were examined during long-term obesity pharmacotherapy trials for 14 different drugs or drug combinations within the theoretical framework of a proportional feedback control system regulating human body weight.
resultsAssuming each obesity drug had a relatively constant effect on average energy intake and did not affect other model parameters, our model correctly predicted that long-term placebo-subtracted energy intake was linearly related to early reductions in energy intake according to a prespecified equation with no free parameters. The simple model explained about 70% of the variance between drug studies with respect to the long-term effects on energy intake, although a significant proportional bias was evident.
conclusionsThe exponential decay over time of obesity pharmacotherapies to suppress energy intake can be interpreted as a relatively constant effect of each drug superimposed on a physiological feedback control system regulating body weight.
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