ArticleJournal of food and drug analysis2016
Hepatoprotective and antidiabetic effects of Pistacia lentiscus leaf and fruit extracts.
Article in Journal of food and drug analysis, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 96 citations in OpenAlex.
- Green Extraction of Phenolic Compounds From Pistacia lentiscus Leaves Coupled With LC-MS Characterization and Structure-Based Enzyme Inhibition Analysis.Chemistry & biodiversity · 2026Article
- Phytochemical Profiling and Biological Evaluation of Pistacia lentiscus L. grown in Chlef (Algeria): An Integrated In Vitro, In Vivo, and In Silico Study.Chemistry & biodiversity · 2026Article
- Ameliorative effect of aqueous leaf extract of Pistacia lentiscus L. against oxaliplatin-induced hepatic injury, oxidative stress, and DNA damage in vitro and in vivo.Medical oncology (Northwood, London, England) · 2025Article
- Comprehensive assessment of antioxidant, antidiabetic, and anti-glycation properties of aqueous and methanolic extracts fromFrontiers in pharmacology · 2025Article
- Innovative Statistical Model Uncover Effective Herbal Medicines Among Personalized Treatment Plans in Persian Medicine: A Small-Scale Study in Type 2 Diabetes.Journal of integrative and complementary medicine · 2024Observational
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- Nutraceutical Content and Biological Properties of Lipophilic and Hydrophilic Fractions of the Phytocomplex fromPlants (Basel, Switzerland) · 2024Article
- The Phenolic Content ofTheScientificWorldJournal · 2024Article
- Analysis of the Chemical Composition and Evaluation of the Antioxidant, Antimicrobial, Anticoagulant, and Antidiabetic Properties ofBiomedicines · 2023Article
- Comparison of Phytochemical Composition, Antibacterial, and Antifungal Activities of Extracts from Three Organs ofMolecules (Basel, Switzerland) · 2023Article
- Metabolomics-Based Profiling via a Chemometric Approach to Investigate the Antidiabetic Property of Different Parts and Origins ofMetabolites · 2023Article
- A Review ofPlants (Basel, Switzerland) · 2023Review
- Investigation of Enzyme Inhibitory Activities, Antioxidant Activities, and Chemical Properties ofIranian journal of pharmaceutical research : IJPR · 2022Article
- Profiling of Essential Oils from the Leaves ofMolecules (Basel, Switzerland) · 2022Article
- Apoptotic, Anti-Inflammatory Activities and Interference with the Glucocorticoid Receptor Signaling of Fractions fromPlants (Basel, Switzerland) · 2022Article
- Article
- Protective Mechanism ofFrontiers in nutrition · 2022Article
- The potential effect of phytochemicals and herbal plant remedies for treating drug-induced hepatotoxicity: a review.Molecular biology reports · 2021Review
- The Beekeeping State and Inventory of Mellifero-Medicinal Plants in the North-Central of Morocco.TheScientificWorldJournal · 2021Article
- Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pistacia lentiscus (Anacardiaceae) is commonly used in folk medicine to treat various diseases. The aim of the present study was to evaluate the hepatoprotective and antioxidant activities of extracts of P. lentiscus leaves (PL) and fruits (PF) against experimentally induced liver damage. Furthermore, characterization of extracts was attempted by a spectroscopic methodology (Fourier transform infrared spectroscopy) and high-performance liquid chromatography with diode array detection analysis. A hepatoprotective potential against paracetamol [165 mg/kg body weight (b.w.)] toxicity was noticed in mice pretreated with the same dose of PL or PF extract (125 mg/kg b.w.) or a combination of both (PL/PF 63/63 mg/kg b.w.), as revealed by an analysis of biochemical parameters (alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities and total bilirubin). These results were confirmed by histological examination of the liver, which revealed significant protection against paracetamol-induced hepatic necrosis. Furthermore, PF extract exhibited a promising antidiabetic activity in streptozotocin-induced diabetic rats, similar to the reference drug glibenclamide (0.91 g/L), a result confirmed by in vitro inhibition of α-amylase. We demonstrated that the leaf crude extract showed the best effect in all tested methods, compared to its fruit counterpart, probably due to the presence of higher amounts of phenolic compounds, as determined by phytochemical and Fourier transform infrared spectroscopy analyses. Moreover, high-performance liquid chromatography with diode array detection led to the identification of six compounds for each part of the plant. Gallic acid, a characteristic compound of Pistacia species, was most abundant in leaves and fruits, while luteolin was detected for the first time in fruits. Obtained activities of P. lentiscus extracts may well be due, at least in part, to the presence of the above compounds.
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