Evidence map›Paper›PMID 28716085›Full record

ArticleBMC complementary and alternative medicine2017

The protective effect of fermented Curcuma longa L. on memory dysfunction in oxidative stress-induced C6 gliomal cells, proinflammatory-activated BV2 microglial cells, and scopolamine-induced amnesia model in mice.

Cheong-Su Eun, Jong-Soon Lim, Jihye Lee, Sam-Pin Lee, Seun-Ah Yang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC complementary and alternative medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 52 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Cheong-Su EunMajor in Food Science and Technology, Keimyung University, Daegu, 42601, Republic of Korea.
Jong-Soon LimThe Center for Traditional Microorganism Resources, Keimyung University, Daegu, 42601, Republic of Korea.
Jihye LeeDepartment of Biomedical Science, Graduate School, Kyungpook National University, Daegu, 38578, Republic of Korea.
Sam-Pin LeeMajor in Food Science and Technology, Keimyung University, Daegu, 42601, Republic of Korea.
Seun-Ah YangMajor in Food Science and Technology, Keimyung University, Daegu, 42601, Republic of Korea. seunahy@kmu.ac.kr.
Keimyung University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCurcuma longa L. is a well-known medicinal plant that has been used for its anti-cancer, neuroprotective, and hepatoprotective effects. However, the neuroprotective effect of fermented C. longa (FCL) has not been reported. Therefore, in this study, the effectiveness of FCL for the regulation of memory dysfunction was investigated in two brain cell lines (rat glioma C6 and murine microglia BV2) and scopolamine-treated mice.

methodsC. longa powder was fermented by 5% Lactobacillus plantarum K154 containing 2% (w/v) yeast extract at 30 °C for 72 h followed by sterilization at 121 °C for 15 min. The protective effects of fermented C. longa (FCL) on oxidative stress induced cell death were analyzed by MTT assay in C6 cells. The anti-inflammatory effects of FCL were investigated by measuring the production of nitric oxide (NO) and prostaglandin E

resultsPretreatment with FCL effectively prevented the cell death induced by oxidative stress in C6 cells. Moreover, FCL inhibited the production NO and PGE

conclusionFCL pretreatment could alleviate scopolamine-induced memory impairment in mice, as well as oxidative stress and inflammation in C6 and BV2 cells, respectively. Thus, FCL might be a useful material for preventing impairment of learning and memory.

Indexed as

PhytotherapyAcetylcholinesteraseAmnesiaAnimalsAnti-Inflammatory AgentsAntioxidantsBrainBrain-Derived Neurotrophic FactorCell LineCurcumaCurcuminCyclic AMP Response Element-Binding ProteinFermentationInflammationInflammation MediatorsLipopolysaccharidesAcetylcholinesteraseAnti-Inflammatory AgentsAntioxidantsBrain-Derived Neurotrophic FactorCreb1 protein, mouseCurcuminCyclic AMP Response Element-Binding ProteinInflammation MediatorsLipopolysaccharidesNeuroprotective AgentsPlant ExtractsScopolamineBV2 microglial cellsC6 glioma cellsFermented Curcuma longa LMemory dysfunctionScopolamine-induced amnesia model

Identifiers

PMID28716085
PMCPMC5514491
OpenAlexW2734857931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.