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ArticleChemical biology & drug design2018

pH-dependent general base catalyzed activation rather than isocyanate liberation may explain the superior anticancer efficacy of laromustine compared to related 1,2-bis(methylsulfonyl)-1-(2-chloroethyl)hydrazine prodrugs.

Philip G Penketh et al.PubMed ↗Full text ↗Publisher ↗

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