ArticleNature communications2017
Real-time monitoring of hydrophobic aggregation reveals a critical role of cooperativity in hydrophobic effect.
Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 116 citations in OpenAlex.
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- Unphysical Structure Collapse in Quantum Mechanics Calculations With Continuum Solvation.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026Article
- Self-Assembly, Aggregation Mechanisms, and Morphological Properties of Asymmetric Perylene Diimide-based Supramolecular Polymers.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Article
- The lipid bilayer strengthens the cooperative network of membrane proteins.Science advances · 2025Article
- Ribosomal L12 stalks recruit elongation factors to speed protein synthesis in Escherichia coli.Communications biology · 2025Article
- Application of a Rational Crystal Contact Engineering Strategy on a Poly(ethylene terephthalate)-Degrading Cutinase.Bioengineering (Basel, Switzerland) · 2025Article
- Plasmonic Single-Molecule Affinity Detection at 10Advanced materials (Deerfield Beach, Fla.) · 2025Article
- Enhanced Photodynamic Therapy Efficacy through Solid Lipid Nanoparticle of Purpurin-18-N-Propylimide Methyl Ester for Cancer Treatment.International journal of molecular sciences · 2024Article
- Steric trapping strategy for studying the folding of helical membrane proteins.Methods (San Diego, Calif.) · 2024Review
- Monophenyl luminescent material with dual-state emission and pH sensitivity for cell imaging.RSC advances · 2024Article
- Going Beyond Host Defence Peptides: Horizons of Chemically Engineered Peptides for Multidrug-Resistant Bacteria.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2023Review
- Solvation thermodynamics from cavity shapes of amino acids.PNAS nexus · 2023Article
- Acidic Conditions Impact Hydrophobe Transfer across the Oil-Water Interface in Unusual Ways.The journal of physical chemistry. B · 2023Article
- Structural features of interfacial water predict the hydrophobicity of chemically heterogeneous surfaces.Chemical science · 2023Article
- Development of a Single-Chain Variable Fragment of CR3022 for a Plasmonic-Based Biosensor Targeting the SARS-CoV-2 Spike Protein.Biosensors · 2022Article
- Aggregation of konjac glucomannan by ethanol under low-alkali treatment.Food chemistry: X · 2022Article
- Elucidation of the key role of Pt···Pt interactions in the directional self-assembly of platinum(II) complexes.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Contiguously hydrophobic sequences are functionally significant throughout the human exome.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Deciphering the evolution of supramolecular nanofibers in solution and solid-state: a combined microscopic and spectroscopic approach.Chemical science · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hydrophobic interaction drives nonpolar solutes to aggregate in aqueous solution, and hence plays a critical role in many fundamental processes in nature. An important property intrinsic to hydrophobic interaction is its cooperative nature, which is originated from the collective motions of water hydrogen bond networks surrounding hydrophobic solutes. This property is widely believed to enhance the formation of hydrophobic core in proteins. However, cooperativity in hydrophobic interactions has not been successfully characterized by experiments. Here, we quantify cooperativity in hydrophobic interactions by real-time monitoring the aggregation of hydrophobic solute (hexaphenylsilole, HPS) in a microfluidic mixer. We show that association of a HPS molecule to its aggregate in water occurs at sub-microsecond, and the free energy change is -5.8 to -13.6 kcal mol
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.