Evidence map›Paper›PMID 28535777›Full record

Trial reportNutrition journal2017

Plasma phospholipid fatty acid profile confirms compliance to a novel saturated fat-reduced, monounsaturated fat-enriched dairy product intervention in adults at moderate cardiovascular risk: a randomized controlled trial.

Oonagh Markey, Dafni Vasilopoulou, Kirsty E Kliem, Albert Koulman, Colette C Fagan, Keith Summerhill, Laura Y Wang, Alistair S Grandison, David J Humphries, Susan Todd and 3 more

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition journal, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02089035 (Replacement of Saturated Fat in Dairy on Total Cholesterol, Vascular Function, Ambulatory Blood Pressure and Cardiovascular Risk Biomarkers), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02089035 nacompletednot on this map

Replacement of Saturated Fat in Dairy on Total Cholesterol, Vascular Function, Ambulatory Blood Pressure and Cardiovascular Risk Biomarkers

TypeinterventionalSponsorUniversity of ReadingRan2014 to 2016Enrolled54ConditionsHypercholesterolemiaArmsMUFA-rich dairy products (UHT milk, cheese and butter), Conventional dairy products (UHT milk, cheese, butter)
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
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  10. Dietary habits and plasma lipid concentrations in a general Japanese population.Metabolomics : Official journal of the Metabolomic Society · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Oonagh MarkeyHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6AP, UK.
Dafni VasilopoulouHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6AP, UK.
Kirsty E KliemAnimal, Dairy and Food Chain Sciences, University of Reading, Reading, RG6 6AP, UK.
Albert KoulmanMRC Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.
Colette C FaganDepartment of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP, UK.
Keith SummerhillMRC Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.
Laura Y WangMRC Elsie Widdowson Laboratory, 120 Fulbourn Road, Cambridge, CB1 9NL, UK.
Alistair S GrandisonDepartment of Food and Nutritional Sciences, University of Reading, Reading, RG6 6AP, UK.
David J HumphriesAnimal, Dairy and Food Chain Sciences, University of Reading, Reading, RG6 6AP, UK.
Susan ToddDepartment of Mathematics and Statistics, School of Mathematical, Physical and Computational Sciences, University of Reading, Reading, RG6 6AX, UK.
Kim G JacksonHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6AP, UK.
David I GivensInstitute for Food, Nutrition and Health, University of Reading, Reading, RG6 6AR, UK.
Julie A LovegroveHugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic Research, University of Reading, Reading, RG6 6AP, UK. j.a.lovegrove@reading.ac.uk.
University of Reading · GBMRC Human Nutrition Research · GBLoughborough University · GB

Funding

Medical Research Council MR/K020218/1
6 · The paper itself

Abstract

backgroundDairy products are a major contributor to dietary SFA. Partial replacement of milk SFA with unsaturated fatty acids (FAs) is possible through oleic-acid rich supplementation of the dairy cow diet. To assess adherence to the intervention of SFA-reduced, MUFA-enriched dairy product consumption in the RESET (REplacement of SaturatEd fat in dairy on Total cholesterol) study using 4-d weighed dietary records, in addition to plasma phospholipid FA (PL-FA) status.

methodsIn a randomised, controlled, crossover design, free-living UK participants identified as moderate risk for CVD (n = 54) were required to replace habitually consumed dairy foods (milk, cheese and butter), with study products with a FA profile typical of retail products (control) or SFA-reduced, MUFA-enriched profile (modified), for two 12-week periods, separated by an 8-week washout period. A flexible food-exchange model was used to implement each isoenergetic high-fat, high-dairy diet (38% of total energy intake (%TE) total fat): control (dietary target: 19%TE SFA; 11%TE MUFA) and modified (16%TE SFA; 14%TE MUFA).

resultsFollowing the modified diet, there was a smaller increase in SFA (17.2%TE vs. 19.1%TE; p < 0.001) and greater increase in MUFA intake (15.4%TE vs. 11.8%TE; p < 0.0001) when compared with the control. PL-FA analysis revealed lower total SFAs (p = 0.006), higher total cis-MUFAs and trans-MUFAs (both p < 0.0001) following the modified diet.

conclusionThe food-exchange model was successfully used to achieve RESET dietary targets by partial replacement of SFAs with MUFAs in dairy products, a finding reflected in the PL-FA profile and indicative of objective dietary compliance.

trial registrationClinicalTrials.gov Identifier: NCT02089035 , date 05-01-2014.

Indexed as

DietPatient ComplianceAdultAgedCardiovascular DiseasesCross-Over StudiesDairy ProductsDietary FatsDouble-Blind MethodFatty AcidsFatty Acids, MonounsaturatedFatty Acids, UnsaturatedFemaleHumansMaleMiddle AgedDietary FatsFatty AcidsFatty Acids, MonounsaturatedFatty Acids, UnsaturatedPhospholipidsCardiovascular diseaseDairy productsDietary fat compositionFatty acidsFood-exchange modelMonounsaturated fatty acidsNutrition assessmentPhospholipidsSaturated fatty acids

Identifiers

PMID28535777
PMCPMC5442645
OpenAlexW2619775716

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.