Evidence map›Paper›PMID 28476766›Full record

Trial reportCirculation2017

Effect of Long-Term Metformin and Lifestyle in the Diabetes Prevention Program and Its Outcome Study on Coronary Artery Calcium.

Ronald B Goldberg, Vanita R Aroda, David A Bluemke, Elizabeth Barrett-Connor, Matthew Budoff, Jill P Crandall, Dana Dabelea, Edward S Horton, Kieren J Mather, Trevor J Orchard and 4 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00038727. Cited by 69 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00038727 phase3completed

Diabetes Prevention Program Outcomes Study

Ran1996Enrolled2,779Registered outcomes17Posted comparisons2ConditionsCancer, CVD, Diabetes MellitusArmsDPPOS Boost Lifestyle, DPPOS Group Lifestyle, Intensive Lifestyle Group Session, Metformin
PMID 19878986PMID 26377054PMID 11832527other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 1 synthesis or guideline pooled it.

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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Ronald B GoldbergFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.). dppmail@bsc.gwu.edu.
Vanita R ArodaFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
David A BluemkeFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
Elizabeth Barrett-ConnorFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
Matthew BudoffFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
Jill P CrandallFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
Dana DabeleaFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
Edward S HortonFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
Kieren J MatherFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
Trevor J OrchardFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
David SchadeFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
Karol WatsonFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
Marinella TemprosaFrom Diabetes Research Institute, University of Miami Miller School of Medicine, FL (R.B.G.); MedStar Health Research Institute, Washington, DC (V.R.A.); National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Washington, DC (D.A.B.); University of California, San Diego (E.B.-C.); Los Angeles Biomedical Research Institute at Harbor-University of California, Los Angeles (M.B.); Albert Einstein College of Medicine, New York, NY (J.P.C.); University of Colorado Denver (D.D.); Joslin Diabetes Center, Boston, MA (E.S.H.); Indiana University School of Medicine, Indianapolis (K.J.M.); University of Pittsburgh Medical Center, PA (T.J.O.); University of New Mexico School of Medicine, Albuquerque (D.S.); University of California Los Angeles School of Medicine (K.W.); and George Washington University Biostatistics Center, Department of Epidemiology and Biostatistics, Rockville, MD (M.T.).
Diabetes Prevention Program Research Group

Funding

PRIMARY PREVENTION TRIAL--DATA COORDINATING CENTERU01DK048489 · NIDDK · GEORGE WASHINGTON UNIVERSITY · PI JABLONSKI, KATHLEEN ANN, TEMPROSA, MARINELLA · 1994 to 2021
$84.8M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Sakeneh Zraika · 1986 to 2026
$41.4M
Maternal Morbidity and Mortality: Risk Factors, Early Detection and Personalized InterventionUL1TR001409 · NCATS · GEORGETOWN UNIVERSITY · PI GONDRE-LEWIS, MARJORIE C, MELLMAN, THOMAS A · 2015 to 2024
$37.8M
Core-010UL1TR001073 · NCATS · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI KELLER, MARLA J, SHAMOON, HARRY · 2013 to 2017
$21.3M
Post-DDP Follow-up StudyU01DK048413 · NIDDK · UNIVERSITY OF WASHINGTON · PI KAHN, STEVEN EMANUEL · 1994 to 2021
$13.7M
PRIMARY PREVENTION TRIAL (DPT-2)U01DK048397 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI NATHAN, DAVID M · 1994 to 2021
$12.0M
NIDDM PRIMARY PREVENTION TRIAL (DPT 2)U01DK048404 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI LAFERRERE, BLANDINE B · 1994 to 2021
$11.6M
PRIMARY PREVENTION TRIAL (DPT-2)U01DK048339 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ARANETA, MARIA ROSARIO GORREZ, MUDALIAR, SUNDER · 1994 to 2022
$11.4M
NIDDM PRIMARY PREVENTION TRIALU01DK048412 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VENDITTI, ELIZABETH MARY · 1994 to 2021
$11.4M
TITLE OMITTEDU01DK048349 · NIDDK · YESHIVA UNIVERSITY · PI CRANDALL, JILL P · 1994 to 2021
$11.0M
PRIMARY PREVENTION TRIALU01DK048443 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI WATSON, KAROL E · 1994 to 2021
$10.2M
Post-DPP Follow-up StudyU01DK048375 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI DABELEA, DANA · 1994 to 2022
$10.0M
NCATS NIH HHS UL1 TR001073NCATS NIH HHS UL1 TR001409NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK078907NIDDK NIH HHS U01 DK048339NIDDK NIH HHS U01 DK048349NIDDK NIH HHS U01 DK048375NIDDK NIH HHS U01 DK048380NIDDK NIH HHS U01 DK048397NIDDK NIH HHS U01 DK048400NIDDK NIH HHS U01 DK048404NIDDK NIH HHS U01 DK048406NIDDK NIH HHS U01 DK048407NIDDK NIH HHS U01 DK048412NIDDK NIH HHS U01 DK048413NIDDK NIH HHS U01 DK048434NIDDK NIH HHS U01 DK048437NIDDK NIH HHS U01 DK048443NIDDK NIH HHS U01 DK048485NIDDK NIH HHS U01 DK048489NIDDK NIH HHS U01 DK048514
6 · The paper itself

Abstract

backgroundDespite the reduced incidence of coronary heart disease with intensive risk factor management, people with diabetes mellitus and prediabetes remain at increased coronary heart disease risk. Diabetes prevention interventions may be needed to reduce coronary heart disease risk. This approach was examined in the DPP (Diabetes Prevention Program) and the DPPOS (Diabetes Prevention Program Outcome Study), a long-term intervention study in 3234 subjects with prediabetes (mean±SD age, 64±10 years) that showed reduced diabetes risk with lifestyle and metformin compared with placebo over 3.2 years.

methodsThe DPPOS offered periodic group lifestyle sessions to all participants and continued metformin in the originally randomized metformin group. Subclinical atherosclerosis was assessed in 2029 participants with coronary artery calcium (CAC) measurements after an average of 14 years of follow-up. The CAC scores were analyzed continuously as CAC severity and categorically as CAC presence (CAC score >0) and reported separately in men and women.

resultsThere were no CAC differences between lifestyle and placebo intervention groups in either sex. CAC severity and presence were significantly lower among men in the metformin versus the placebo group (age-adjusted mean CAC severity, 39.5 versus 66.9 Agatston units,

conclusionsMetformin may protect against coronary atherosclerosis in prediabetes and early diabetes mellitus among men. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT00038727.

Indexed as

CalciumLife StyleAdultAgedCoronary Artery DiseaseCoronary VesselsDiabetes Mellitus, Type 2Drug Administration ScheduleFemaleFollow-Up StudiesHumansHypoglycemic AgentsMaleMetforminMiddle AgedTreatment OutcomeCalciumHypoglycemic AgentsMetforminclinical trial [publication type]coronary artery diseaseprediabetic statetherapeutics

Identifiers

PMID28476766
PMCPMC5526695

What OpenQuestion holds

Texttitle and abstract
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.