← Diet, exercise & lifestyle × cardiovascular events

TrialCirculation2022

Effects of Long-term Metformin and Lifestyle Interventions on Cardiovascular Events in the Diabetes Prevention Program and Its Outcome Study.

Ronald B Goldberg et al.PubMed ↗Full text ↗Publisher ↗

Published long after NCT00004992 ended. The report of the trial’s main result is not on the map, and the numbers here are shown and do not vote.

What the trial testedas reported · 3,234 people · 2022

Range includes no effect

No clear effect on cardiovascular events

Doesn’t vote: a later paper about the trial

+3%−22% to +37%

Smaller than almost all for cardiovascular events

As reported

HR 1.03, 95% CI 0.78–1.37

One number in the abstract

the abstract, start to end

… metformin versus placebo hazard ratio 1.03 (95% CI, 0.78-1.37; …

← favours treatmentfavours comparator →
could be chance
Cardiovascular events
HR 1.030.78–1.37
MetforminDiet, exercise & lifestyleCardiovascular events
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2 trials

Full record →Abstract, authors, funding and every citing paper · PMID 35603600