Evidence map›Paper›PMID 28386795›Full record

Observational studyJournal of endocrinological investigation2017

"Metabolic and cardiovascular response to exercise in patients with type 1 diabetes".

I Turinese, P Marinelli, M Bonini, M Rossetti, G Statuto, T Filardi, A Paris, A Lenzi, S Morano, P Palange

Registry-linked trialOpen access · bronzeAbstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of endocrinological investigation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05478707 (Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
4.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05478707 phase2recruitingstarted 2023, after this paper: background citation

Therapeutic Strategies for Microvascular Dysfunction in Type 1 Diabetes

Ran2023Enrolled47Registered outcomes5Posted comparisons0ConditionsDiabetes Mellitus, Type 1, Endothelial DysfunctionArmsDulaglutide, Placebo
PMID 29310645PMID 24742660PMID 22732108PMID 27295427PMID 27436611PMID 27633186PMID 30270019PMID 11842075PMID 1348845PMID 15161743PMID 16109070PMID 16644702other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Association of HbA1c with VOMetabolites · 2022
    Review
  6. Maximal Oxygen Uptake, VOInternational journal of environmental research and public health · 2022
    Article
  7. Review
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

I TurineseDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale dell' Università 37, 00185, Rome, Italy. irene.turinese@uniroma1.it.
P MarinelliDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
M BoniniDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
M RossettiDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
G StatutoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
T FilardiDepartment of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico 151, 00185, Rome, Italy.
A ParisDepartment of Clinical Medicine, "Sapienza" University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
A LenziDepartment of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico 151, 00185, Rome, Italy.
S MoranoDepartment of Experimental Medicine, "Sapienza" University of Rome, Viale del Policlinico 151, 00185, Rome, Italy.
P PalangeDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Viale dell' Università 37, 00185, Rome, Italy.
Sapienza University of Rome · ITPoliclinico Umberto I · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePhysical activity is an effective therapeutic tool for cardiovascular risk prevention. However, exercise aerobic capacity of patients with type 1 diabetes (T1DM) has not been thoroughly investigated. Aim of the present study is to evaluate exercise aerobic capacity in patients with T1DM compared to a normal control population.

methodsThis observational study included 17 T1DM patients and 17 matched healthy volunteers. Cardiopulmonary exercise test (CPET) was conducted on an electronically-braked cycle ergometer. Blood samples were collected for evaluation of glycemia and lactate levels.

resultsMean oxygen uptake at peak exercise (V'O

conclusionsPatients affected by T1DM have a worse exercise tolerance than normal subjects. The two groups differed by RER which can be greatly influenced by the substrate type utilized to produce energy. Because of the impaired carbohydrate utilization, T1DM subjects may use a larger amount of lipid substrates, such hypothesis could be strengthened by the lower lactate levels found in T1DM group at peak exercise. The lack of correlation between exercise tolerance and disease-related variables suggests that the alterations found could be independent from the glycemic levels.

Indexed as

AdultBlood GlucoseDiabetes Mellitus, Type 1ExerciseExercise TestExercise ToleranceFemaleHeart RateHumansMaleOxygen ConsumptionBlood GlucoseCardiopulmonary exercise testDiabetes mellitusExercise physiologyPhysical activity

Identifiers

PMID28386795
OpenAlexW2604672185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.