ArticleEuropean journal of nutrition2018
Immune dysfunction and increased oxidative stress state in diet-induced obese mice are reverted by nutritional supplementation with monounsaturated and n-3 polyunsaturated fatty acids.
Article in European journal of nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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17 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Comparison of enteral immunonutrition and enteral nutrition in patients undergoing gastric cancer surgery: a systematic review and meta-analysis of randomized, controlled trials.The Journal of international medical research · 2024Pooled it
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- Docosahexaenoic Acid Consumption Early in Life Improves Immune Dysfunction in High-Fat Diet-Fed Wistar Rats in a Sex-Specific Manner.Molecular nutrition & food research · 2026Article
- n-3 PUFA-supplemented perioperative immunonutrition on postoperative outcomes in gastric cancer: a systematic review and meta-analysis.Frontiers in nutrition · 2025Review
- Alterations in the composition of meibomian gland secretions in patients with meibomian gland dysfunction based on Raman spectroscopy.Frontiers in medicine · 2025Article
- Deciphering the role of oleic acid in diabetic retinopathy: an empirical analysis of monounsaturated fatty acids.Nutrition & metabolism · 2024Article
- Docosahexaenoic Acid Delivery Systems, Bioavailability, Functionality, and Applications: A Review.Foods (Basel, Switzerland) · 2022Review
- COVID-19 preventives consumed in South Africa versus other Sub-Saharan African countries.Health SA = SA Gesondheid · 2022Article
- Macrophage-Mediated Immune Responses: From Fatty Acids to Oxylipins.Molecules (Basel, Switzerland) · 2021Review
- The Role of Immune Cells in Oxi-Inflamm-Aging.Cells · 2021Review
- Covid 19: Diet Composition and Health.Nutrients · 2021Review
- Dietary recommendations during the COVID-19 pandemic.Nutrition reviews · 2021Review
- Quantitative Profiling of Oxylipin Reveals the Mechanism of Pien-Tze-Huang on Alcoholic Liver Disease.Evidence-based complementary and alternative medicine : eCAM · 2021Article
- How to Exercise During Coronavirus Quarantine?Caspian journal of internal medicine · 2020Review
- Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione.Frontiers in immunology · 2020Article
- Improvement of Redox State and Functions of Immune Cells as Well as of Behavioral Response in Aged Mice After Two-Week Supplementation of Fermented Milk with Probiotics.Current microbiology · 2019Article
- Ultraviolet light-C increases antioxidant capacity of the strawberry (Food science & nutrition · 2017Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeObesity is associated with impaired immune defences and chronic low levels of inflammation and oxidation. In addition, this condition may lead to premature aging. The aim of the study was to evaluate the effects of a nutritional supplementation with monounsaturated and n-3 polyunsaturated fatty acids on several functions and oxidative stress parameters in peritoneal immune cells of obese mice, as well as on the life span of these animals.
methodsObesity was induced in adult female ICR/CD1 by the administration of a high-fat diet (HFD) for 14 weeks. During the last 6 weeks of HFD feeding, one group of obese mice received the same HFD, supplemented with 1500 mg of 2-hydroxyoleic acid (2-OHOA) and another with 3000 mg of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Several functions and oxidative stress parameters of peritoneal leukocytes were evaluated.
resultsThe groups of obese mice treated with 2-OHOA or with EPA and DHA showed a significant improvement in several functions such as chemotaxis, phagocytosis, digestion capacity, Natural killer activity and lymphoproliferation in response to mitogens. All of these functions, which were decreased in obese mice, increased reaching similar levels to those found in non-obese controls. Both treatments also improved oxidative stress parameters such as xanthine oxidase activity, which decreased, catalase activity and glutathione levels, which increased.
conclusionThese data suggest that dietary supplementation with monounsaturated and n-3 polyunsaturated fatty acids could be an effective nutritional intervention to restore the immune response and oxidative stress state, which are impaired in obese mice.
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