← Statins × lipids

SynthesisThe Cochrane database of systematic reviews2016

Chronotherapy versus conventional statins therapy for the treatment of hyperlipidaemia.

Jose Manuel Izquierdo-Palomares et al.PubMed ↗Full text ↗Publisher ↗

  • Evening statin administrationno clear effectNo clear effect on total cholesterol, no clear effect on LDL cholesterol, no clear effect on HDL cholesterol.Nothing cleared the noise.

What the trial testedas reported · 767 people · 2016

Range includes no effect

No clear effect on total cholesterol

+4.33−1.36 to +10.0

evening statin administration vs morning statin administration

As reported

difference 4.33, 95% CI −1.36 to 10.0

Range includes no effect

No clear effect on LDL cholesterol

+4.85mg/dL−0.87 to +10.6

evening statin administration vs morning statin administration

As reported

difference 4.85 mg/dL, 95% CI −0.87 to 10.6 · the paper's word: low-density lipoprotein cholesterol (LDL-C) levels

Range includes no effect

No clear effect on HDL cholesterol

+0.54−1.08 to +2.17

evening statin administration vs morning statin administration

As reported

difference 0.54, 95% CI −1.08 to 2.17 · the paper's word: high-density lipoprotein cholesterol (HDL-C)

Range includes no effect

No clear effect on triglycerides

−8.91−22.0 to +4.17

evening statin administration vs morning statin administration

As reported

difference −8.91, 95% CI −22.0 to 4.17

+1 more in the walkthrough ↓

Who was studied, and how

767people with dyslipidemia, in this paper

The trial randomly assignedassigned by chance

evening statin administration
morning statin administration

No clear effect on total cholesterol+4.33

No clear effect on LDL cholesterol+4.85

No clear effect on HDL cholesterol+0.54

randomised

the abstract, start to end

… of a difference in total cholesterol (MD 4.33, 95% CI -1.36 to 10.01), 514 participants, five trials, mean follow-up 9 weeks, low-quality evidence), low-density lipoprotein cholesterol (LDL-C) levels (MD 4.85 mg/dL, 95% CI -0.87 to 10.57, 473 participants, five trials, mean follow-up 9 weeks, low-quality evidence), high-density lipoprotein cholesterol (HDL-C) (MD 0.54, 95% CI -1.08 to 2.17, 514 participants, five trials, mean follow-up 9 weeks, low-quality evidence) or triglycerides (MD -8.91, 95% CI -22 to 4.17, 510 …

… between morning and evening intake (OR 0.71, 95% CI 0.44 to 1.15, 556 …

← favours treatmentfavours comparator →
could be chance
Total cholesterolevening statin administration vs morning statin administration
4.33−1.36 to 10.0
Low-density lipoprotein cholesterol (LDL-C) levelsevening statin administration vs morning statin administration
4.85−0.87 to 10.6
High-density lipoprotein cholesterol (HDL-C)evening statin administration vs morning statin administration
0.54−1.08 to 2.17
Triglyceridesevening statin administration vs morning statin administration
−8.91−22.0 to 4.17
Adverse eventsevening statin administration vs morning statin administration
OR 0.710.44–1.15
StatinsLipidsAdverse events & safety
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Full record →Abstract, authors, funding and every citing paper · PMID 27888640