Evidence map›Paper›PMID 27840293›Full record

ArticleThe Journal of nutritional biochemistry2017

Comparative proteomic analyses of the parietal lobe from rhesus monkeys fed a high-fat/sugar diet with and without resveratrol supplementation, relative to a healthy diet: Insights into the roles of unhealthy diets and resveratrol on function.

Aaron M Swomley, Judy C Triplett, Jeriel T Keeney, Govind Warrier, Kevin J Pearson, Julie A Mattison, Rafael de Cabo, Jian Cai, Jon B Klein, D Allan Butterfield

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of nutritional biochemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Future directions of resveratrol research.Nutrition and healthy aging · 2018
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Aaron M SwomleyDepartment of Chemistry, University of Kentucky, Lexington, KY 40536, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA.
Judy C TriplettDepartment of Chemistry, University of Kentucky, Lexington, KY 40536, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA.
Jeriel T KeeneyDepartment of Chemistry, University of Kentucky, Lexington, KY 40536, USA.
Govind WarrierDepartment of Chemistry, University of Kentucky, Lexington, KY 40536, USA.
Kevin J PearsonSanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA; Molecular and Biomedical Pharmacology and Nutrition, University of Kentucky, Lexington, KY 40536, USA.
Julie A MattisonTranslational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Rafael de CaboTranslational Gerontology Branch, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Jian CaiProteomics Center, University of Louisville, Louisville, KY 40202, USA.
Jon B KleinProteomics Center, University of Louisville, Louisville, KY 40202, USA.
D Allan ButterfieldDepartment of Chemistry, University of Kentucky, Lexington, KY 40536, USA; Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA. Electronic address: dabcns@uky.edu.
National Institute on Aging · USUniversity of Kentucky · USUniversity of Louisville · US

Funding

Calorie restriction and agingZIAAG000368 · NIA · NATIONAL INSTITUTE ON AGING · PI DE CABO, RAFAEL · 2009 to 2025
$6.9M
Resveratrol treatment in monkeysZIAAG000369 · NIA · NATIONAL INSTITUTE ON AGING · PI MATTISON, JULIE · 2009 to 2017
$858k
Intramural NIH HHS Z99 AG999999
6 · The paper itself

Abstract

A diet consisting of a high intake of saturated fat and refined sugars is characteristic of a Western-diet and has been shown to have a substantial negative effect on human health. Expression proteomics were used to investigate changes to the parietal lobe proteome of rhesus monkeys consuming either a high fat and sugar (HFS) diet, a HFS diet supplemented with resveratrol (HFS+RSV), or a healthy control diet for 2 years. Here we discuss the modifications in the levels of 12 specific proteins involved in various cellular systems including metabolism, neurotransmission, structural integrity, and general cellular signaling following a nutritional intervention. Our results contribute to a better understanding of the mechanisms by which resveratrol functions through the up- or down-regulation of proteins in different cellular sub-systems to affect the overall health of the brain.

Indexed as

2',3'-Cyclic Nucleotide 3'-PhosphodiesteraseAnimalsBrainDietary SugarsDietary SupplementsDiet, HealthyDiet, High-FatDisease Models, AnimalGlutamate-Ammonia LigaseMacaca mulattaMaleParietal LobeProteomeReproducibility of ResultsResveratrolSignal Transduction2',3'-Cyclic Nucleotide 3'-PhosphodiesteraseDietary SugarsGlutamate-Ammonia LigaseProteomeResveratrolStilbenesBrainProteomicsResveratrolRhesus monkeyWestern diet

Identifiers

PMID27840293
PMCPMC5665370
OpenAlexW2530901999

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.