ArticleScientific reports2016
Sex differences in colonization of gut microbiota from a man with short-term vegetarian and inulin-supplemented diet in germ-free mice.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed.
- Sex differences in the gut microbiome and related metabolites: role in cardiometabolic disease.Gut microbes · 2026Review
- The gut-heart axis in coronary artery disease: a scoping and narrative review of sex-based microbial and metabolic disparities.Biology of sex differences · 2026Article
- Association of fermented food intake with the prevalence of depressive symptoms and suicidal ideation in men and women stratified by age: the Korea National Health and Nutrition Examination Survey 2014-2022.Frontiers in nutrition · 2026Article
- Effect of a fructooligosaccharides fraction fromBioscience of microbiota, food and health · 2026Article
- Parabacteroides as a promising target for disease intervention: current stage and pending issues.NPJ biofilms and microbiomes · 2025Review
- 5-aminosalicylic acid alleviates colitis and protects intestinal barrier function by modulating gut microbiota in mice.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Fecal microbiota transplantation: application scenarios, efficacy prediction, and factors impacting donor-recipient interplay.Frontiers in microbiology · 2025Review
- Evaluation of Functional Components ofFoods (Basel, Switzerland) · 2024Article
- Human-derived bacterial strains mitigate colitis via modulating gut microbiota and repairing intestinal barrier function in mice.BMC microbiology · 2024Article
- Sex-specific differences in intestinal microbiota associated with cardiovascular diseases.Biology of sex differences · 2024Article
- A comprehensive overview of microbiome data in the light of machine learning applications: categorization, accessibility, and future directions.Frontiers in microbiology · 2024Review
- The Impacts of Fecal Microbiota Transplantation from Same Sex on the Symptoms of Ulcerative Colitis Patients.Polish journal of microbiology · 2023Article
- Sex- and Age-Dependent Associations betweenMicroorganisms · 2023Article
- Antibiotic-induced socio-sexual behavioral deficits are reversed via cecal microbiota transplantation but not androgen treatment.Brain, behavior, & immunity - health · 2023Article
- Microbiota-associated mechanisms underlying sexual dimorphism in hypertension.Microbiota and host · 2023Article
- Dietary fiber modulates gut microbiome and metabolome in a host sex-specific manner in a murine model of aging.Frontiers in molecular biosciences · 2023Article
- Alteration of pro-carcinogenic gut microbiota is associated with clear cell renal cell carcinoma tumorigenesis.Frontiers in microbiology · 2023Article
- Sex as a Biological Variable in Nutrition Research: From Human Studies to Animal Models.Annual review of nutrition · 2022Review
- Description of a Newly IsolatedNutrients · 2022Article
- The Efficacy of Fecal Transplantation and Bifidobacterium Supplementation in Ameliorating Propionic Acid-Induced Behavioral and Biochemical Autistic Features in Juvenile Male Rats.Journal of molecular neuroscience : MN · 2022Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gnotobiotic mouse model is generally used to evaluate the efficacy of gut microbiota. Sex differences of gut microbiota are acknowledged, yet the effect of recipient's gender on the bacterial colonization remains unclear. Here we inoculated male and female germ-free C57BL/6J mice with fecal bacteria from a man with short-term vegetarian and inulin-supplemented diet. We sequenced bacterial 16S rRNA genes V3-V4 region from donor's feces and recipient's colonic content. Shannon diversity index showed female recipients have higher bacteria diversity than males. Weighted UniFrac principal coordinates analysis revealed the overall structures of male recipient's gut microbiota were significantly separated from those of females, and closer to the donor. Redundancy analysis identified 46 operational taxonomic units (OTUs) differed between the sexes. The relative abundance of 13 OTUs were higher in males, such as Parabacteroides distasonis and Blautia faecis, while 33 OTUs were overrepresented in females, including Clostridium groups and Escherichia fergusonii/Shigella sonnei. Moreover, the interactions of these differential OTUs were sexually distinct. These findings demonstrated that the intestine of male and female mice preferred to accommodate microbiota differently. Therefore, it is necessary to designate the gender of gnotobiotic mice for complete evaluation of modulatory effects of gut microbiota from human feces upon diseases.
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